Physical and sexual abuse, depression and alcohol use disorders in adolescents: onsets and outcomes
Physical and sexual abuse, depression and alcohol use disorders in adolescents: onsets and outcomes
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DOI：
10.1016/s0376-8716(02)00254-5
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发表时间：
2003-01-24
影响因子：
4.2
通讯作者：
Martin, CS
中科院分区：
文献类型：
--
作者：
Clark, DB;De Bellis, MD;Martin, CS
患有酒精使用障碍(AUD)的青少年通常患有严重抑郁障碍(MDD)。虽然身体虐待和性虐待(PS虐待)在患有AUDS的青少年中很常见，但PS虐待对MDD和AUD共病的影响尚未确定。先前存在的PS滥用对患有AUDS的青少年成年期结局的影响也没有得到充分的研究。这项研究考察了青春期PS滥用、MDD和AUD之间的关系，以及相关的年轻人结果。青少年(平均16.4岁；14-18岁)来自临床和社区来源，分为四组：(1)AUD+PS滥用(n=154)，(2)仅AUD(n=255)，(3)仅PS滥用(N 74)，(4)对照组(n=268)。受试者通过青壮年(19岁或以上)进行纵向评估。措施包括对DSM-IV AUD和MDD的访谈评估，被归类为“主要的”或“次要的”，以及酒精消费和抑郁的问卷测量。原发MDD先于AUD，继发性MDD起病晚于AUD。PS滥用加速了原发MDD、继发性MDD和AUD的发病。虽然在青年评估中，受影响的青少年在饮酒和抑郁方面通常都有所改善，但大多数患有青春期AUD的人在青年时期患有AUDS，MDD在有PS滥用史的人中仍然很常见。这些结果表明AUD青少年中的MDD可能部分归因于PS的滥用。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
Adolescents with alcohol use disorders (AUDs) often have major depressive disorder (MDD). While physical abuse and sexual abuse (PS Abuse) have been observed to be common in adolescents with AUDs, the influence of PS Abuse on comorbid MDD and AUD has not been determined. The effect of pre-existing PS Abuse on the young adulthood outcomes of adolescents with AUDs has also not been adequately explored. This study examined the relationships among PS Abuse, MDD, and AUD in adolescence, as well as related young adult outcomes. Adolescents (mean age: 16.4 years; range: 14-18 years) were recruited from clinical and community sources and classified into four groups: (1) AUD+PS Abuse (n = 154), (2) AUD only (n = 255), (3) PS Abuse only (n 74), and (4) Controls (n = 268). Subjects were longitudinally assessed through young adulthood (age 19 years or older). Measures included interview assessments of DSM-IV AUD and MDD, classified as "primary" or "secondary", and questionnaire measures of alcohol consumption and depression. Primary MDD preceded AUD whereas secondary MDD had a later onset than AUD. PS Abuse accelerated the onsets of primary MDD, secondary MDD and AUD. While affected adolescents had typically improved in both alcohol consumption and depression at the young adult assessment, the majority of those with adolescent AUD had AUDs in young adulthood, and MDD remained common in those with a history of PS Abuse. These results indicate that MDD among adolescents with AUD may be partly attributable to PS Abuse. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.