Galectins: Major Signaling Modulators Inside and Outside the Cell
Galectins: Major Signaling Modulators Inside and Outside the Cell
复制标题
DOI：
10.2174/1566524014666140603101953
复制
发表时间：
2014-01-01
影响因子：
2.5
通讯作者：
Laderach, D. J.
中科院分区：
文献类型：
--
作者：
Compagno, D.;Jaworski, F. M.;Laderach, D. J.
半乳糖凝集素通过作用于不同的信号通路来控制细胞行为。这些分子的大部分生物活性依赖于细胞外糖缀合物的识别和多价相互作用的建立，从而触发适应性生物反应。然而，半乳糖凝集素也在细胞内的不同隔室中检测到，其中它们的调节功能仍然知之甚少。因此，更深入地了解整个半乳糖凝集素信号体及其在细胞行为中的影响是至关重要的，以便描绘新的策略，专门操纵半乳糖凝集素的表达和功能。这篇综述总结了我们目前对半乳糖凝集素激活的信号通路的认识，它们的聚糖依赖性和它们被激活并具有生物学相关性的细胞区室。
Galectins control cell behavior by acting on different signaling pathways. Most of the biological activities ascribed to these molecules rely upon recognition of extracellular glycoconjugates and establishment of multivalente interactions, which trigger adaptive biological responses. However, galectins are also detected within the cell in different compartments, where their regulatory functions still remain poorly understood. A deeper understanding of the entire galectin signalosome and its impact in cell behavior is therefore essential in order to delineate new strategies to specifically manipulate both galectin expression and function. This review summarizes our current knowledge of the signaling pathways activated by galectins, their glycan dependence and the cellular compartment where they become activated and are biologically relevant.