Gonadotropin-releasing hormone signaling: An information theoretic approach.
Gonadotropin-releasing hormone signaling: An information theoretic approach.
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促性腺激素释放激素信号传导：一种信息论方法。
DOI：
10.1016/j.mce.2017.07.028
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发表时间：
2018
影响因子：
4.1
通讯作者：
Voliotis M
中科院分区：
文献类型：
--
作者：
Voliotis M
促性腺激素释放激素（Gonadotropin-releasing hormone, GnRH）是一种介导生殖中枢控制的肽激素，通过g蛋白偶联受体（主要是gq偶联）起作用，介导GnRH对促黄体生成素和促卵泡激素的合成和分泌的影响。我们对GnRH受体信号网络了解很多，但GnRH是短脉冲分泌的，而促性腺激素是如何解码这种脉冲信号的，我们所知甚少。类似地，单细胞测量揭示了GnRH反应中相当大的细胞间异质性，但这种变异性对信号传导的影响在很大程度上是未知的。基于常微分方程的数学模型已被用于探索脉冲动力学的解码，信息理论衍生的统计测量越来越多地用于解决细胞-细胞变异性对信号通路传递的信息量的影响。在这里，我们描述了GnRH信号传导的两种方法，重点是从信息论方法中获得的新见解，以及为什么GnRH以脉冲形式分泌的基本问题。
Gonadotropin-releasing hormone (GnRH) is a peptide hormone that mediates central control of reproduction, acting via G-protein coupled receptors that are primarily Gqcoupled and mediate GnRH effects on the synthesis and secretion of luteinizing hormone and follicle-stimulating hormone. A great deal is known about the GnRH receptor signaling network but GnRH is secreted in short pulses and much less is known about how gonadotropes decode this pulsatile signal. Similarly, single cell measures reveal considerable cell-cell heterogeneity in responses to GnRH but the impact of this variability on signaling is largely unknown. Ordinary differential equation-based mathematical models have been used to explore the decoding of pulse dynamics and information theory-derived statistical measures are increasingly used to address the influence of cell-cell variability on the amount of information transferred by signaling pathways. Here, we describe both approaches for GnRH signaling, with emphasis on novel insights gained from the information theoretic approach and on the fundamental question of why GnRH is secreted in pulses.