Role of Calcium Homeostasis in Alzheimer's Disease.
Role of Calcium Homeostasis in Alzheimer's Disease.
复制标题
钙稳态在阿尔茨海默氏病中的作用。
DOI：
10.2147/ndt.s350939
复制
发表时间：
2022
影响因子：
3.2
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Ge M;Zhang J;Chen S;Huang Y;Chen W;He L;Zhang Y
阿尔茨海默病 (AD) 是一种与大脑中的老年斑 (SP) 和神经原纤维缠结 (NFT) 相关的神经退行性疾病。随着人口老龄化，AD已成为最常见的痴呆症。然而，导致AD的机制仍在研究中，目前尚无治疗其的特效药物。因此，进一步研究AD的发病机制，开发治疗AD的新药仍然是当务之急。多项研究表明AD中细胞内钙稳态失调，这与β淀粉样蛋白（Aβ）沉积、tau蛋白过度磷酸化、突触可塑性异常和细胞凋亡有关，所有这些都参与了AD的发生和发展。此外，一些基于钙稳态与AD联系途径的研究在AD治疗中取得了成果。本文全面探讨钙稳态与AD发病机制的关系，为今后AD的探索和新型治疗药物的研发提供理论依据。
Alzheimer’s disease (AD) is a neurodegenerative disease associated with senile plaques (SP) and neurofibrillary tangles (NFTs) in the brain. With aging of the population, AD has become the most common form of dementia. However, the mechanisms leading to AD are still under investigation, and there are currently no specific drugs for its treatment. Therefore, further study on the pathogenesis of AD to develop new drugs for AD treatment remains a top priority. Several studies have suggested that intracellular calcium homeostasis is dysregulated in AD, and this has been implicated in the deposition of amyloid β (Aβ), hyperphosphorylation of tau protein, abnormal synaptic plasticity, and apoptosis, all of which are involved in the occurrence and development of AD. In addition, some based on pathways linking calcium homeostasis and AD have achieved results in AD treatment. This review comprehensively explores the relationship between calcium homeostasis and the pathogenesis of AD to provide a theoretical basis for the future exploration of AD and the development of novel therapeutic drugs.