Plasma immunoreactive relaxin levels in pregnant and nonpregnant women.
Plasma immunoreactive relaxin levels in pregnant and nonpregnant women.
复制标题
孕妇和非孕妇的血浆免疫反应性松弛素水平。
DOI：
10.1210/jcem-47-5-1106
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
B. Steinetz
中科院分区：
文献类型：
--
作者：
E. O'Byrne;B. T. Carriere;L. Sørensen;A. Segaloff;C. Schwabe;B. Steinetz
利用 Sherwood 等人的 RIA 程序（经 O'Byrne 和 Steinetz 针对异源血浆样品进行修改），在从人类志愿者获得的血浆样品中测量了免疫反应性松弛素。在男性样本中未检测到免疫反应性激素，在非孕妇血浆中也很少检测到免疫反应性激素。免疫反应性松弛素早在妊娠第四周就存在，并且在整个妊娠过程中均可检测到。免疫反应性松弛素在怀孕早期往往较高，并且在分娩前没有像许多其他物种那样出现峰值。我们的结果与布莱恩特和同事的结果不一致，他们报告说男性、非怀孕女性和怀孕女性的免疫反应性松弛素水平很高。提出了造成这种差异的可能原因。
Immunoreactive relaxin was measured in plasma samples obtained from human volunteers utilizing the RIA procedure of Sherwood et al., as modified by O'Byrne and Steinetz for heterologous plasma samples. Immunoreactive hormone was not detected in samples obtained from men, and only rarely in plasma of nonpregnant women. Immunoreactive relaxin was present as early as the fourth week of pregnancy and was detectable throughout the course of gestation. Immunoreactive relaxin tended to be higher early in pregnancy, and there was no peak just before parturition as occurs in many other species. Our results are at variance with those of Bryant and coworkers, who reported high levels of immunoreactive relaxin in men and nonpregnant as well as pregnant women. The possible reasons for this discrepancy are presented.