Nonmuscle Tissues Contribution to Cancer Cachexia.
Nonmuscle Tissues Contribution to Cancer Cachexia.
复制标题
DOI：
10.1155/2015/182872
复制
发表时间：
2015
影响因子：
4.6
通讯作者：
Busquets S
中科院分区：
文献类型：
--
作者：
Argilés JM;Stemmler B;López-Soriano FJ;Busquets S
恶病质是一种与癌症相关的综合征，其特征是体重减轻、肌肉和脂肪组织消耗以及炎症，通常与厌食有关。尽管肌肉组织占体重的 40% 以上，并且似乎是恶病质期间发生的消耗的主要组织，但最近的发展表明，脂肪（棕色和白色）、大脑、肝脏、肠道和心脏等组织/器官直接参与恶病质过程，并可能导致肌肉消耗。这表明恶病质确实是一种多器官综合征。考虑到所有这些，本综述的目的是检查非肌肉组织在癌症恶病质中的影响。
Cachexia is a syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting, and inflammation, being often associated with anorexia. In spite of the fact that muscle tissue represents more than 40% of body weight and seems to be the main tissue involved in the wasting that occurs during cachexia, recent developments suggest that tissues/organs such as adipose (both brown and white), brain, liver, gut, and heart are directly involved in the cachectic process and may be responsible for muscle wasting. This suggests that cachexia is indeed a multiorgan syndrome. Bearing all this in mind, the aim of the present review is to examine the impact of nonmuscle tissues in cancer cachexia.