Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish
Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish
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DOI：
10.1021/es502711c
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发表时间：
2014-11-04
影响因子：
11.4
通讯作者：
Suter, Marc J. -F.
中科院分区：
文献类型：
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作者：
Macikova, Petra;Groh, Ksenia J.;Suter, Marc J. -F.
这项研究调查了捷克共和国和瑞士的废水和河流中皮质类固醇信号干扰物的发生情况。用高效液相色谱-串联质谱仪检测到36个目标化合物，其中间接影响糖皮质激素信号转导的唑类抗真菌药物的含量高达6.4mg/L。用糖皮质激素受体(GR)-CALUX生物测定法测定糖皮质激素受体(GR)介导的活性，地塞米松等效浓度范围为
This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 mu g/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from