When does gastric atrophy develop in Japanese children?
When does gastric atrophy develop in Japanese children?
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DOI：
10.1111/j.1523-5378.2008.00611.x
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发表时间：
2008-08-01
期刊：
影响因子：
4.4
通讯作者：
Nakajima, Shigemi
中科院分区：
文献类型：
--
作者：
Kato, Seiichi;Kikuchi, Shogo;Nakajima, Shigemi
背景资料：长期幽门螺杆菌感染会导致胃萎缩和肠上皮化生等炎症后遗症，这被认为会增加患胃恶性肿瘤的风险。我们以前报道过日本儿童H.幽门感染，主要在胃窦。方法和结果：本研究对131例（79例男孩）H。pylori感染者的年龄和胃萎缩程度之间的关系进行了重新分析。对131例患者的胃窦和46例患者的胃体进行了组织学检查。分别在13名和1名患者中观察到2级和3级胃窦萎缩：平均年龄为12.1岁。2例患者（11岁和14岁）有2级体萎缩，但没有患者有3级。胃窦（p = 0.97）和胃体（p = 0.59）0级、1级和2级或3级萎缩患者的年龄无显著差异。没有2级或3级萎缩的患者肠上皮化生无论是在胃窦或在corps.Conclusions：本研究的结果需要仔细解释，因为回顾性分析。然而，在胃癌高发国家，根除H。幽门螺杆菌在儿童时期可以证明更有效地防止胃萎缩，最终，癌症的发展。
Background: Long-term Helicobacter pylori infection causes inflammatory sequelae such as atrophy and intestinal metaplasia in the stomach, which is thought to increase the risk of developing gastric malignancy. We previously reported that gastric atrophy can develop in Japanese children with H. pylori infection, predominantly in the antrum. However, detailed data about the age of children with atrophy are largely lacking.Methods and results: In the present study, 131 children (79 boys) with H. pylori infection were re-analyzed for an association between age and the grade of gastric atrophy. The gastric antrum was histologically evaluated in all 131 patients and the corpus in 46 patients. Grade 2 and 3 antral atrophy was observed in 13 and one patients, respectively: the mean age was 12.1 years. Two patients (11 and 14 years old) had grade 2 corpus atrophy but no patients had grade 3. No significant difference was found in age among patients with grade 0, 1 and 2 or 3 atrophy in the antrum (p = .97) and in the corpus (p = .59). None of the patients with grade 2 or 3 atrophy had intestinal metaplasia either in the antrum or in the corpus.Conclusions: The results of the present study require a careful interpretation because of the retrospective analysis. In high-risk countries of gastric cancer, however, eradicating H. pylori in childhood could prove more effective in preventing gastric atrophy, ultimately, the development of cancer.