Effects of depressive symptoms and mental health quality of life on use of highly active antiretroviral therapy among HIV-seropositive women
Effects of depressive symptoms and mental health quality of life on use of highly active antiretroviral therapy among HIV-seropositive women
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DOI：
10.1097/00042560-200208010-00005
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发表时间：
2002-08-01
期刊：
影响因子：
--
通讯作者：
Young, M
中科院分区：
文献类型：
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作者：
Cook, JA;Cohen, MH;Young, M
本研究探讨了抑郁症状和精神健康生活质量对艾滋病毒血清阳性妇女使用高效抗逆转录病毒治疗（HAART）的影响。从1996年到1998年，每半年收集一次前瞻性队列研究的数据。妇女报告使用抗逆转录病毒治疗，健康和心理健康状况，人口统计学，社会和行为因素，CD 4计数和病毒载量也进行了评估。随机效应回归模型估计了抑郁症状和心理健康生活质量对HAART使用概率的纵向影响，控制了临床指标（CD 4计数，病毒载量，症状存在），人口统计学（种族，年龄，教育），行为因素（药物/酒精使用，临床试验参与），服务特征（保险状况，心理健康服务利用）和研究地点。高水平的抑郁症状和精神健康生活质量差，他们显着降低了HAART利用的可能性。接受心理健康服务显着增加利用HAART的概率。艾滋病毒血清反应呈阳性的妇女，其特点是在精神健康状况不佳，不太可能使用高效抗逆转录病毒疗法，而那些接受治疗的精神健康问题更有可能使用高效抗逆转录病毒疗法。这些研究结果表明，加强妇女获得心理治疗的努力可能会增加她们对最新艾滋病毒疗法的使用。
This study examines the effects of depressive symptoms and mental health quality of life on utilization of highly active antiretroviral therapy (HAART) among HIV-seropositive women. Data were collected biannually from 1996 through 1998 in a prospective cohort study. Women reported use of antiretroviral therapy, health and mental health status, demographics, and social and behavioral factors; CD4 count and viral load also were assessed. Random effects regression models estimated the longitudinal effects of depressive symptoms and mental health quality of life on the probability of HAART utilization, controlling for clinical indicators (CD4 count, viral load, symptom presence), demographics (race, age, education), behavioral factors (drug/alcohol use, clinical trials participation), service features (insurance status, mental health service utilization), and study site. High levels of depressive symptoms and poor mental health quality of life were found, and they significantly reduced the probability of HAART utilization. Receiving mental health services significantly increased the probability of utilizing HAART. HIV-seropositive women characterized as being in poor mental health were less likely to use HAART, whereas those receiving treatment of mental health difficulties were more likely to use HAART. These findings suggest that efforts to enhance women's access to psychological treatment may increase their use of the latest HIV therapies.