Improving uptake of screening for colorectal cancer: a study on invitation strategies and different test kit use
Improving uptake of screening for colorectal cancer: a study on invitation strategies and different test kit use
复制标题
DOI：
10.1097/meg.0000000000000314
复制
发表时间：
2015-05-01
影响因子：
2.1
通讯作者：
Leja, Marcis
中科院分区：
文献类型：
--
作者：
Santare, Daiga;Kojalo, Ilona;Leja, Marcis
目的本研究的目的是比较使用邮寄测试进行结直肠癌筛查。我们评估的影响，提前通知信和提醒信，并分析了比例不当处理tests.Materials和方法随机选择的居民拉脱维亚年龄在50-74岁被分配到三个不同的测试系统之一：无论是愈创木粪隐血试验（gFOBT）或两个实验室为基础的免疫化学试验（FIT）-FOB金或OC-传感器。一半的目标人群收到了预先通知函;所有无应答者都收到了提醒函。结果gFOBT、FOB Gold和OC传感器的筛查率分别为31.2%、44.7%和47.4（gFOBT vs. FOB Gold的比值比0.55; 95%置信区间0.51-0.60; FOB Gold vs. OC-探头的比值比0.90; 95%置信区间0.83-0.98）。gFOBT组的摄取通过预先通知信得到改善（7.7%，P < 0.0001）。30.9%的退回检测是在收到提醒函后收到的。由于处理不当而无法分析的检测比例为gFOBT为0.9%，FOB Gold为4.4%，OC传感器为0.2%（gFOBT与OC传感器的P = 0.002;所有比较与FOB Gold的P < 0.001）。收到提醒函对参与至关重要，但使用预先通知函主要对gFOBT很重要。对于FOB Gold，处理不当的测试比例明显更高。版权所有（C）2015威科医疗集团All rights reserved.
Objective The aim of this study was to compare the uptake of mail-delivered tests for colorectal cancer screening. We assessed the effect of an advance notification letter and a reminder letter, and analysed the proportion of inappropriately handled tests.Materials and methods Fifteen thousand randomly selected residents of Latvia aged 50-74 years were allocated to receive one of three different test systems: either a guaiac faecal occult blood test (gFOBT) or one of two laboratory-based immunochemical tests (FIT) -FOB Gold or OC-Sensor. Half of the target population received an advance notification letter; all nonresponders were sent a reminder letter.Results The uptake of screening was 31.2% for the gFOBT, 44.7% for FOB Gold and 47.4% for the OC-Sensor (odds ratio 0.55; 95% confidence interval 0.51-0.60 for gFOBT vs. FOB Gold; odds ratio 0.90; 95% confidence interval 0.83-0.98 for FOB Gold vs. OC-Sensor). The uptake in the gFOBT group was improved by the advance notification letter (7.7%, P < 0.0001). 30.9% returned tests were received after the reminder letter. The proportion of tests that could not be analysed because of inadequate handling was 0.9% for gFOBT, 4.4% for FOB Gold and 0.2% for the OC-Sensor (P = 0.002 for gFOBT vs. OC-Sensor; P < 0.001 for all comparisons vs. FOB Gold).Conclusion The use of FIT resulted in higher uptake. Receipt of a reminder letter was critical to participation, but the use of an advance notification letter was important mainly for gFOBT. The proportion of inappropriately handled tests was markedly higher for FOB Gold. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.