Challenges to the Measurement of Estradiol: An Endocrine Society Position Statement
Challenges to the Measurement of Estradiol: An Endocrine Society Position Statement
复制标题
DOI：
10.1210/jc.2012-3780
复制
发表时间：
2013-04-01
影响因子：
5.8
通讯作者：
Wierman, Margaret E.
中科院分区：
文献类型：
--
作者：
Rosner, William;Hankinson, Susan E.;Wierman, Margaret E.
目的：本研究的目的是评估雌二醇临床检测在其应用中的现状。参与者：参与者由内分泌学会理事会任命，负责利用已发表的数据和专家意见实现目标。证据：数据是通过在线数据库（主要是 PubMed、Ovid MEDLINE、Google Scholar）从已发表的来源收集的，以及内分泌学会的临床和实验室经验。 参与者。共识过程：该声明是委员会的努力成果，并由每位成员审查。临床事务委员会、内分泌学会理事会和 JCEM 审稿人审查了手稿并提出了建议。结论：生物体液中雌二醇的测量对于人类从摇篮到坟墓的生物学都很重要。除了在性发育中发挥中心作用外，它对皮肤、血管、骨骼、肌肉、凝血、肝细胞、脂肪组织、肾脏、胃肠道、大脑、肺和胰腺也有显着影响。其血浆浓度的变化与冠状动脉疾病、中风和乳腺癌有关。尽管现代免疫分析和基于液相色谱/串联质谱的雌二醇方法相当适合不孕症的诊断和治疗（尽管如此，不精确性和方法之间的差异仍然存在问题），但在非生殖组织中似乎至关重要的极低浓度是一个单独且更困难的问题。这种雌二醇水平太低，无法准确或精确地进行常规测量，需要进一步发展分析方法和雌二醇标准化方式。 (临床内分泌代谢杂志 98: 1376-1387, 2013)
Objective: The objective of the study was to evaluate the current state of clinical assays for estradiol in the context of their applications.Participants: The participants were appointed by the Council of The Endocrine Society and charged with attaining the objective using published data and expert opinion.Evidence: Data were gathered from published sources via online databases (principally PubMed, Ovid MEDLINE, Google Scholar), and the clinical and laboratory experience of the participants.Consensus Process: The statement was an effort of the committee and was reviewed by each member. The Clinical Affairs Committee, the Council of The Endocrine Society, and JCEM reviewers reviewed the manuscript and made recommendations.Conclusions: The measurement of estradiol in biological fluids is important in human biology from cradle to grave. In addition to its centrality in sexual development, it has significant effects on skin, blood vessels, bone, muscle, coagulation, hepatic cells, adipose tissue, the kidney, the gastrointestinal tract, brain, lung, and pancreas. Alterations in its plasma concentration have been implicated in coronary artery disease, stroke, and breast cancer. Although modern immunoassays and liquid chromatography/tandem mass spectrometry-based methods for estradiol are reasonably well suited to the diagnosis and management of infertility (nonetheless, imprecision and method-to-method differences remain problematic), the very low concentrations that appear to be crucial in nonreproductive tissues are a separate and more difficult issue. Such levels of estradiol are too low to be routinely measured accurately or precisely, and further evolution of analytical methods and the way in which estradiol is standardized is needed. (J Clin Endocrinol Metab 98: 1376-1387, 2013)