PARASITE-SPECIFIC ANERGY IN HUMAN FILARIASIS - INSIGHTS AFTER ANALYSIS OF PARASITE ANTIGEN-DRIVEN LYMPHOKINE PRODUCTION
PARASITE-SPECIFIC ANERGY IN HUMAN FILARIASIS - INSIGHTS AFTER ANALYSIS OF PARASITE ANTIGEN-DRIVEN LYMPHOKINE PRODUCTION
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DOI：
10.1172/jci112982
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发表时间：
1987-05-01
影响因子：
15.9
通讯作者：
OTTESEN, EA
中科院分区：
文献类型：
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作者：
NUTMAN, TB;KUMARASWAMI, V;OTTESEN, EA
通过检测10例无症状微丝虫病患者、13例象皮病患者和6例正常北美人外周血单个核细胞(PBMC)或PBMC亚群中淋巴因子的产生，研究了班氏丝虫病的抗原特异性无反应性。在每组患者中，淋巴因子反应的动力学以及对有丝分裂原和非寄生虫抗原的反应没有显著差异。与之形成鲜明对比的是，当检测抗原诱导的淋巴因子产生时，大多数微丝虫病患者既不能产生白介素2(IL-2)，也不能产生γ-干扰素(即无反应者)，少数人(低反应者，通常微丝虫病水平相当低)产生的水平明显低于象皮病患者，这些患者都对寄生虫抗原表现出强烈的反应。去除贴壁细胞或T8+细胞都不会影响微丝虫病患者的寄生虫特异性无能，这表明患有这种最常见的班克罗夫氏丝虫病临床表现的患者对寄生虫具有T细胞耐受性。
The antigen-specific unresponsiveness seen in bancroftian filariasis was studied by examining lymphokine production in peripheral blood mononuclear cells (PBMC) or PBMC subpopulations from 10 patients with asymptomatic microfilaremia, 13 patients with elephantiasis and 6 normal North Americans. In each group of patients, the kinetics of the lymphokine response and the response to mitogens and nonparasite antigens did not differ significantly. In marked contrast, when antigen-induced lymphokine production was examined, most patients with microfilaremia were unable to produce either interleukin 2 (IL-2) or .gamma.-interferon (i.e., were nonresponders), and the few who could (hyporesponders, generally with quite low microfilaremia levels) did so at levels significantly less than those of patients with elephantiasis, all of whom showed strong responses to parasite antigen. Removal of neither adherent cells or T8+ cells affected the parasite-specific anergy seen in those with microfilaremia, suggesting a state of T cell tolerance to the parasite in patients with this most common clinical manifestation of bancroftian filariasis.