WebLogo: A sequence logo generator
WebLogo: A sequence logo generator
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DOI：
10.1101/gr.849004
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发表时间：
2004-06-01
期刊：
影响因子：
7
通讯作者：
Brenner, SE
中科院分区：
文献类型：
--
作者：
Crooks, GE;Hon, G;Brenner, SE
WebLogo生成序列标识，即多序列比对中模式的图形表示。序列标识提供了比共有序列更丰富和更精确的序列相似性描述，并且可以快速揭示比对的重要特征，否则难以察觉。每个徽标由一堆字母组成，一堆字母代表序列中的每个位置。每个堆叠的总高度指示该位置处的序列保守性（以位测量），而堆叠内的符号的高度反映该位置处的相应氨基酸或核酸的相对频率。WebLogo最近得到了增强，增加了额外的功能和选项，提供了一个方便且高度可配置的序列徽标生成器。命令行界面和完整的开放WebLogo源代码可用于本地安装和自定义。
WebLogo generates sequence logos, graphical representations of the patterns within a multiple sequence alignment. Sequence logos provide a richer and more precise description of sequence similarity than consensus sequences and can rapidly reveal significant features of the alignment otherwise difficult to perceive. Each logo consists of stacks of letters, one stack for each position in the sequence. The overall height of each stack indicates the sequence conservation at that position (measured in bits), whereas the height of symbols within the stack reflects the relative frequency of the corresponding amino or nucleic acid at that position. WebLogo has been enhanced recently with additional features and options, to provide a convenient and highly configurable sequence logo generator. A command line interface and the complete, open WebLogo source code are available for local installation and customization.