Acute corticosterone sexually dimorphically facilitates social learning and inhibits feeding in mice
Acute corticosterone sexually dimorphically facilitates social learning and inhibits feeding in mice
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DOI：
10.1016/j.neuropharm.2013.07.011
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发表时间：
2013-12-01
影响因子：
4.7
通讯作者：
Valsecchi, Paola
中科院分区：
文献类型：
--
作者：
Choleris, Elena;Cazzin, Laura;Valsecchi, Paola
在许多物种中，社会学习是占优势的和适应性的，然而，我们对其神经生物学机制知之甚少。社会学习受到动机和情绪的调节，这种方式通常是性别上的二态。此外，压力荷尔蒙强烈地调节了与社会认知相关的社会认知过程。这是否真的适用于社交学习，目前还不得而知。我们研究了应激激素皮质酮(CORT)对雄性和雌性小鼠食物偏好的社会传递(STEP)的急性影响。在短暂的社会互动中，观察者(OBS)从同性示威者(DEM)那里获得食物偏好。分别以1.0、2.5、5.0 mg/kg、0.1%乙醇载体和0.9%生理盐水给OBS大鼠，30min前10min给予生理盐水。在接受了相同剂量的Curt的其他小鼠中，评估了血浆Curt的水平，并在治疗后10 mm进行了或没有经历过30 mm的社交互动。外源性Curt引起的血浆水平与昼夜节律高峰时的水平相当，并促进了这一步骤，无论是在食物偏好的持续时间还是最小有效剂量方面，男性的反应都比女性更多。Curt还性二型抑制取食，雌性表现出比雄性更大的剂量反应。生理盐水和乙醇车辆也在性方面促进了STFP并减少了喂食，但比Curt少。这些结果表明，Curt促进了社会学习，就像社会认可一样。因此，Curt一般可能会增加社会信息处理。(C)2013爱思唯尔有限公司。保留所有权利。
In numerous species social learning is predominant and adaptive, yet, we know little of its neurobiological mechanisms. Social learning is modulated by motivations and emotions, in a manner that is often sexually dimorphic. Additionally, stress hormones acutely modulate the related social cognitive process of social recognition. Whether this is true even for social learning is currently unknown. We investigated the acute effects of the stress hormone corticosterone (CORT) on the social transmission of food preferences (STEP) in male and female mice. During a brief social interaction an observer (OBS) acquires a food preference from a same-sex demonstrator (DEM). CURT (1.0, 2.5, 5.0 mg/kg), its ethanol vehicle (0.1%), and saline solution (0.9%) were administered intraperitoneally to the OBS, 10 min before a 30-min social interaction. Levels of plasma CURT were assessed in other mice that had received the same doses of CURT and either had or had not gone through a 30 mm social interaction 10 mm post-treatment. Exogenous CURT elicited levels of plasma level comparable to those seen at the peak of the circadian cycle and facilitated the STEP with males responding more than females both in terms of the duration of the food preference and the minimum effective dose. CURT also sexually dimorphically inhibited feeding, with females showing a greater dose-response than males. Saline solution and ethanol vehicles also sexually dimorphically facilitated the STFP and reduced feeding, but less than CURT did. These results indicate that CURT facilitates social learning, like social recognition. Hence, CURT may generally increase social information processing. (C) 2013 Elsevier Ltd. All rights reserved.