A structurally detailed finite element human head model for simulation of transcranial magnetic stimulation
A structurally detailed finite element human head model for simulation of transcranial magnetic stimulation
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DOI：
10.1016/j.jneumeth.2009.01.010
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发表时间：
2009-04-30
影响因子：
3
通讯作者：
Mogul, David Jeffery
中科院分区：
文献类型：
--
作者：
Chen, Ming;Mogul, David Jeffery
利用有限元模型 (FEM) 进行的头部计算研究已被用来研究各种胸罩在电磁 (EM) 场相互作用的现象，包括使用经颅磁刺激 (TMS) 对头部进行磁刺激、用于电惊厥治疗的大脑直接电刺激以及脑电图源定位。然而，尚未开发出足够复杂的人体头部模型来研究这些情况下的生物物理学，该模型利用区域和细胞水平上的结构，并在不同电导率和方向的组织之间提供明确的平滑边界。构建如此精确的头部模型的主要障碍是复杂的建模过程，包括 3D 对象重建和优化的网格划分。在这项研究中，通过结合计算机断层扫描和磁共振图像，生成了一个结构详细的人体头部有限元模型，其中包括脑回和脑沟水平的细节。此外，头部模型中包含了包含穿过新皮质层的锥体神经元传导过程的皮质柱，从而提供了细胞水平或附近的结构。这些改进提供了一个更加现实的模型来研究 TMS 对新皮质脑电生理学的影响。 (C) 2009 Elsevier B.V. 保留所有权利。
Computational studies of the head utilizing finite element models (FEMs) have been used to investigate a wide variety of bra in-electromagnetic (EM) field interaction phenomena including magnetic stimulation of the head using transcranial magnetic stimulation (TMS), direct electric stimulation of the brain for electroconvulsive therapy, and electroencephalography source localization. However, no human head model of sufficient complexity for studying the biophysics under these circumstances has been developed which utilizes structures at both the regional and cellular levels and provides well-defined smooth boundaries between tissues of different conductivities and orientations. The main barrier for building such accurate head models is the complex modeling procedures that include 3D object reconstruction and optimized meshing. In this study, a structurally detailed finite element model of the human head was generated that includes details to the level of cerebral gyri and sulci by combining computed tomography and magnetic resonance images. Furthermore, cortical columns that contain conductive processes of pyramidal neurons traversing the neocortical layers were included in the head model thus providing structure at or near the cellular level. These refinements provide a much more realistic model to investigate the effects of TMS on brain electrophysiology in the neocortex. (C) 2009 Elsevier B.V. All rights reserved.