HOST RANGE OF MINK CELL FOCUS-INDUCING VIRUSES
HOST RANGE OF MINK CELL FOCUS-INDUCING VIRUSES
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DOI：
10.1016/0042-6822(85)90362-9
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发表时间：
1985-01-01
期刊：
影响因子：
3.7
通讯作者：
HARTLEY, JW
中科院分区：
文献类型：
--
作者：
CLOYD, MW;THOMPSON, MM;HARTLEY, JW
重组水貂细胞聚焦诱导（MCF）类鼠逆转录病毒的物种宿主范围在体外确定，并与异嗜性和双嗜性鼠病毒的宿主范围特性进行比较。与异嗜性和双嗜性病毒相比，MCF 病毒感染的哺乳动物物种数量受到限制。来自小鼠、大鼠、水貂、雪貂和猫的细胞系对 MCF 感染敏感，某些病毒分离株可以感染兔细胞，但来自中国仓鼠、水牛、蝙蝠、狗、猴子和人类的细胞对大多数 MCF 病毒的感染具有抵抗力。后者的一些细胞的抵抗力通过与异种病毒的表型混合而被消除，这表明MCF物种宿主范围是由病毒包膜-细胞表面相互作用介导的。各种 MCF 分离株的宿主范围一致性和敏感性的独特物种分布与其他证据得出的结论一致，即 MCF 病毒属于不同于异嗜性和双嗜性病毒的一类。
The species host range of the recombinant, mink cell focus-inducing (MCF) class of murine retroviruses was determined in vitro and compared to the host range properties of xenotropic and amphotropic murine viruses. In contrast to xenotropic and amphotropic viruses, MCF viruses were restricted in the number of mammalian species they would infect. Cell lines from mouse, rat, mink, ferret and cat were susceptible to MCF infection and certain virus isolates could infect rabbit cells, but cells from Chinese hamster, buffalo, bat, dog, monkey and human were resistant to infection by most MCF viruses. The resistance of some of the latter cells was abrogated by phenotypic mixing with xenotropic virus, which demonstrated that MCF species host range was mediated by virus envelope-cell surface interaction. The host range uniformity of the various MCF isolates and the unique species distribution of sensitivity are consistent with the conclusion from other evidence that the MCF viruses comprise a class distinct from xenotropic and amphotropic viruses.