DNA damage associated with mitosis and cytokinesis failure.
DNA damage associated with mitosis and cytokinesis failure.
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有丝分裂是一个高度动态的过程，目的是将基因组材料的相同拷贝分离成两个子细胞。有丝分裂过程的失败产生携带异常染色体数目的细胞。这些细胞在连续细胞分裂时倾向于成为致瘤性的，因此需要从群体中去除以避免癌症形成。有丝分裂进程失败的细胞确实会激活细胞死亡或细胞周期阻滞途径，然而，这些机制尚未得到很好的理解。越来越多的证据表明，在有丝分裂失败期间和之后形成的从头DNA损伤是启动这些途径的原因之一。在这里，我们分析了几个不同的故障在有丝分裂和胞质分裂，导致从头DNA损伤的产生。
Mitosis is a highly dynamic process, aimed at separating identical copies of genomic material into two daughter cells. A failure of the mitotic process generates cells that carry abnormal chromosome numbers. Such cells are predisposed to become tumorigenic upon continuous cell division and thus need to be removed from the population to avoid cancer formation. Cells that fail in mitotic progression indeed activate cell death or cell cycle arrest pathways, however, these mechanisms are not well understood. Growing evidence suggest that the formation of de novo DNA damage during and after mitotic failure is one of the causal factors that initiate those pathways. Here, we analyze several distinct malfunctions during mitosis and cytokinesis that lead to de novo DNA damage generation.
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