Hepatocellular carcinoma in the thalassaemia syndromes
Hepatocellular carcinoma in the thalassaemia syndromes
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DOI：
10.1046/j.1365-2141.2003.04732.x
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发表时间：
2004-01-01
影响因子：
6.5
通讯作者：
Bisconte, MG
中科院分区：
文献类型：
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作者：
Borgna-Pignatti, C;Vergine, G;Bisconte, MG
肝细胞癌（HCC）经常并发继发于病毒感染或铁超载的肝硬化。因此，患有地中海贫血综合征的患者在理论上具有发展肿瘤的高风险。我们收集了意大利地中海贫血治疗中心的患者数据。确定了22例HCC病例; 15例为男性。诊断时，平均年龄为45 +/- 11岁，平均血清铁蛋白为1764 +/- 1448 mug/l。86%的人感染了丙型肝炎病毒。22例中有19例是在1993年以后确诊的，这表明随着地中海贫血患者人口的老龄化，这一问题变得越来越频繁。
Hepatocellular carcinoma (HCC) frequently complicates hepatic cirrhosis secondary to viral infection or iron overload. Therefore, patients affected by thalassaemia syndromes have a theoretically high risk of developing the tumour. We collected data on patients attending Italian centres for the treatment of thalassaemia. Twenty-two cases of HCC were identified; 15 were male. At diagnosis, the mean age was 45 +/- 11 years and the mean serum ferritin was 1764 +/- 1448 mug/l. Eighty-six percent had been infected by hepatitis C virus. Nineteen of 22 cases were diagnosed after 1993, suggesting that this problem is becoming more frequent with the aging population of thalassaemia patients.