Adherence to 7-Day Primaquine Treatment for the Radical Cure of P-vivax in the Peruvian Amazon
Adherence to 7-Day Primaquine Treatment for the Radical Cure of P-vivax in the Peruvian Amazon
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DOI：
10.4269/ajtmh.2010.09-0521
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发表时间：
2010-06-01
影响因子：
3.3
通讯作者：
Gamboa, Dionicia
中科院分区：
文献类型：
--
作者：
Grietens, Koen Peeters;Soto, Veronica;Gamboa, Dionicia
尽管是免费的，但在秘鲁亚马逊伊基托斯-瑙塔公路沿线的患者中，估计有62.2%的患者坚持使用7天的伯氨喹来根治间日疟原虫。不遵守的主要原因是与当地体液疾病观念有关的感知不良影响，这些观念认为疟疾会产生身体的炎热状态，而特有的炎热的医疗治疗进一步加剧了这种情况。值得注意的是，患者愿意坚持治疗的前3天，在此期间症状最明显，包括典型的寒战。然而，随着症状的减轻，药物的加重特征超过了坚持治疗的好处。提高社区对伯喹在防止疟疾进一步传播方面的作用的认识，并在社区一级建立一个现实的直接监督治疗摄取系统，有望提高该地区对根治间日疟原虫的坚持。
Despite being free of charge, treatment adherence to 7-day primaquine for the radical cure of Plasmodium vivax was estimated at 62.2% among patients along the Iquitos-Nauta road in the Peruvian Amazon. The principal reason for non-adherence was the perceived adverse effects related to local humoral illness conceptions that hold that malaria produces a hot state of body, which is further aggravated by the characteristically hot medical treatment. Notably, patients were willing to adhere to the first 3 days of treatment during which symptoms are most apparent and include the characteristic chills. Nevertheless, as symptoms abate, the perceived aggravating characteristics of the medication outweigh the perceived advantages of treatment adherence. Improving community awareness about the role of primaquine to prevent further malaria transmission and fostering a realistic system of direct observed treatment intake, organized at community level, can be expected to improve adherence to the radical cure of P. vivax in this area.