Hippocampal subfield volumetry in patients with subcortical vascular mild cognitive impairment.
Hippocampal subfield volumetry in patients with subcortical vascular mild cognitive impairment.
复制标题
皮层下血管轻度认知障碍患者海马亚野容积测定
DOI：
10.1038/srep20873
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发表时间：
2016-02-15
影响因子：
4.6
通讯作者：
Han Y
中科院分区：
文献类型：
--
作者：
Li X;Li D;Li Q;Li Y;Li K;Li S;Han Y
记忆障碍是皮层下血管性轻度认知障碍（svMCI）或遗忘性轻度认知障碍（aMCI）患者的典型特征。海马在从短期记忆到长期记忆的信息巩固中起着重要作用，它是一个异质性结构，由几个解剖和功能上不同的子区组成。然而，不同的海马亚区是否受到svMCI病理的差异和选择性影响，以及这些海马亚区异常变化在svMCI和aMCI患者之间是否不同，在很大程度上是未知的。本研究共纳入26例svMCI患者、26例aMCI患者和26例根据年龄、性别和受教育年限匹配的健康对照。我们利用FreeSurfer提供的海马亚区自动分割方法来估计海马的几个亚区，包括角状脑区（CA）、齿状回（DG）、枕下和枕前。与对照组相比，svMCI患者的左侧骨下、骨下前和右侧CA4/DG出现明显萎缩。有趣的是，我们还发现svMCI组和aMCI组右CA1的体积有显著差异。综上所述，我们的研究结果揭示了海马亚区对svMCI病理的特异性易感性，并确定了svMCI和aMCI患者之间不同的海马亚区萎缩模式。
Memory impairment is a typical characteristic of patients with subcortical vascular mild cognitive impairment (svMCI) or with amnestic mild cognitive impairment (aMCI). The hippocampus, which plays an important role in the consolidation of information from short-term memory to long-term memory, is a heterogeneous structure that consists of several anatomically and functionally distinct subfields. However, whether distinct hippocampal subfields are differentially and selectively affected by svMCI pathology and whether these abnormal changes in hippocampal subfields are different between svMCI and aMCI patients are largely unknown. A total of 26 svMCI patients, 26 aMCI patients and 26 healthy controls matched according to age, gender and years of education were enrolled in this study. We utilized an automated hippocampal subfield segmentation method provided by FreeSurfer to estimate the volume of several hippocampal subfields, including the cornu ammonis (CA) areas, the dentate gyrus (DG), the subiculum and the presubiculum. Compared with controls, the left subiculum and presubiculum and the right CA4/DG displayed significant atrophy in patients with svMCI. Interestingly, we also found significant differences in the volume of the right CA1 between the svMCI and aMCI groups. Taken together, our results reveal region-specific vulnerability of hippocampal subfields to svMCI pathology and identify distinct hippocampal subfield atrophy patterns between svMCI and aMCI patients.