On the nitrile effect in L-rhamnopyranosylation
On the nitrile effect in L-rhamnopyranosylation
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DOI：
10.1016/j.carres.2006.03.036
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发表时间：
2006-07-24
影响因子：
3.1
通讯作者：
Patel, Mitesh
中科院分区：
文献类型：
--
作者：
Crich, David;Patel, Mitesh
结果表明，使用5%的乙腈或丙腈在二氯甲烷中的功能，以增加β-选择性的L-吡喃鼠李糖基化反应的数量进行的硫代糖苷方法与活化的1-苯亚磺酰基哌啶/三氟甲磺酸酐对。使用更大量的乙腈或丙腈导致形成含有很少偶联产物的复杂反应混合物，但从中可以分离出Ritter型产物。(c)2006爱思唯尔有限公司保留所有权利。
It is shown that the use of 5% acetonitrile or propionitrile in dichloromethane functions to increase the beta-selectivity of a number of L-rhamnopyranosylation reactions conducted by the thioglycoside method with activation by the 1-benzenesulfinyl piperidine/trifluoromethanesulfonic anhydride couple. The use of more significant quantities of acetonitrile or propionitrile results in the formation of complex reaction mixtures containing little coupled product, but from which Ritter-type products can be isolated. (c) 2006 Elsevier Ltd. All rights reserved.