Rabbit urethral regeneration using small intestinal submucosa onlay grafts
Rabbit urethral regeneration using small intestinal submucosa onlay grafts
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DOI：
10.1016/s0090-4295(98)00114-9
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发表时间：
1998-07-01
期刊：
影响因子：
2.1
通讯作者：
Thor, KB
中科院分区：
文献类型：
--
作者：
Kropp, BP;Ludlow, JK;Thor, KB
目标.目的探讨小肠黏膜下层（SIS）是否能促进尿道再生。将20只雄性白色新西兰兔分配至3个实验组之一。第1组（n = 4）行单纯尿道切开闭合术。第2组（n = 8），第二个对照组，采用宿主兔的全层包皮皮移植物进行覆盖尿道成形术。第3组（n = 8）行SIS移植物覆盖尿道成形术。所有8个SIS贴附移植物均促进了由血管化良好的胶原蛋白和平滑肌支持的正常兔上皮的再生。包皮游离覆盖移植物维持了一个角质化的鳞状上皮细胞，其支撑性较差，导致尿道憩室的形成。SIS覆盖补片尿道成形术促进兔尿道再生。(C)1998年，Elsevier Science Inc. All rights reserved.
Objectives. To determine if small intestinal submucosa (SIS) can evoke urethral regeneration.Methods. Twenty male white New Zealand rabbits were assigned to one of three experimental groups. Group 1 (n = 4) underwent simple urethrotomy and closure. Group 2 (n = 8), a second control group, underwent an onlay urethroplasty with a graft of full-thickness preputial skin from the host rabbit. Group 3 (n = 8) underwent an onlay urethroplasty with an SIS graft.Results. All eight SIS onlay grafts promoted regeneration of the normal rabbit epithelium supported by a well-vascularized collagen and smooth muscle backing. Preputial free onlay grafts maintained a keratinizing squamous cell epithelium with a poor supportive backing, which resulted in the formation of urethral diverticulum.Conclusions. SIS onlay patch grafts for urethroplasty promote rabbit urethral regeneration. (C) 1998, Elsevier Science Inc. All rights reserved.