Autoradiographic studies on the distribution of arsenic in mice and hamsters administered 74As-arsenite or -arsenate.
Autoradiographic studies on the distribution of arsenic in mice and hamsters administered 74As-arsenite or -arsenate.
复制标题
DOI：
10.1111/j.1600-0773.1982.tb01023.x
复制
发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
A. Lindgren;Marie Vahter;Lennart Dencker
中科院分区：
文献类型：
--
作者：
A. Lindgren;Marie Vahter;Lennart Dencker
全身放射自显影结合其他测定的组织水平的74砷在小鼠中，5分钟。30天后静脉注射的74砷-亚砷酸盐（As III）或砷酸盐（As V），显示较高的器官浓度和全身保留的砷在As III小鼠相比，As V小鼠。与As III小鼠相比，As V小鼠中只有肾脏（短时间间隔）和骨骼中的水平较高。砷钒在骨骼中的积累可能是由于砷酸盐与磷酸盐的相似性，因此砷酸盐可能取代了磷灰石晶体中的磷酸盐。砷的长期滞留最明显的是在头发和皮肤，鳞状上皮上胃肠道（口腔，食道，食管胃粘膜的一部分），附睾，甲状腺，透镜和骨骼。在毛发、皮肤和上胃肠道中的蓄积可归因于与角蛋白的结合，角蛋白在鳞状上皮中含量较高。砷在金黄地鼠体内的分布与在小鼠体内的分布相似。无机砷的不良影响报告的研究结果的意义进行了讨论。
Whole-body autoradiography in combination with other determinations of tissue levels of 74As-arsenic in mice, 5 min. to 30 days after intravenous injections of 74As-arsenite (As III) or -arsenate (As V), showed higher organ concentrations and whole-body retention of arsenic in the As III mice as compared to the As V mice. Only the kidneys (at short time intervals) and the skeleton had higher levels in the As V mice as compared to the As III mice. The skeletal accumulation of As V is probably due to the resemblance of the arsenate to phosphate, so that arsenate may substitute for phosphate in the apatite crystal. The long-term retention of arsenic was most apparent in hair and skin, squamous epithelium of the upper gastrointestinal tract (oral cavity, oesophagus, and the oesophageal part of the stomach mucosa), the epididymis, thyroid, lens and skeleton. The accumulation in hair, skin and the upper gastrointestinal tract may be ascribed to a binding to keratin, the content of which is high in squamous epithelia. The distribution of arsenic in golden hamsters was similar to that found in mice. The significance of the findings in relation to reported adverse effects of inorganic arsenic is discussed.