APPLICATION OF INVIVO NMR-SPECTROSCOPY TO CANCER
APPLICATION OF INVIVO NMR-SPECTROSCOPY TO CANCER
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DOI：
10.1002/mrm.1910010410
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发表时间：
1984-01-01
影响因子：
3.3
通讯作者：
GLICKSON, JD
中科院分区：
文献类型：
--
作者：
EVANOCHKO, WT;NG, TC;GLICKSON, JD
对分离的肿瘤细胞、切除的肿瘤和体内肿瘤的核磁共振光谱研究进行了批判性评论。虽然大多数的研究检查处理31 P NMR光谱，多核NMR调查的潜在效用的强调。本次审查的一个主要主题是在体内NMR光谱的实验肿瘤生物学和临床诊断和癌症的管理的潜在应用的评估。数据表明，这种方法可能被证明是有用的，在区分相对良好的血管化的需氧肿瘤和血管化不良的缺氧肿瘤。这可以为识别对X射线辐射或高温有反应的肿瘤提供基础。初步实验指出，体内NMR光谱学将能够检测肿瘤对化疗，X射线辐射和热疗的反应，并且还可以检测药物诱导的对宿主生存至关重要的组织的毒性。
A critical review is presented of NMR spectroscopic studies of isolated tumor cells, excised tumors, and in vivo tumors. Although the majority of the studies examined deal with31P NMR spectroscopy, the potential utility of multinuclear NMR investigations is emphasized. A major theme of this review is the evaluation of the potential applications of in vivo NMR spectroscopy to experimental tumor biology and to the clinical diagnosis and management of cancer. Data are presented demonstrating that this method may prove useful in distinguishing between relatively well vascularized aerobic tumors and poorly vascularized hypoxic tumors. This could provide a basis for identifying tumors responsive to X radiation or hyperthermia. Preliminary experiments point to the possibility that in vivo NMR spectroscopy will be capable of detecting tumor response to chemotherapy, X radiation, and hyperthermia and may also detect drug‐induced toxicity to tissues vital to the survival of the host.