Serum uric acid and metabolic syndrome in Taiwanese adults
Serum uric acid and metabolic syndrome in Taiwanese adults
复制标题
DOI：
10.1016/j.metabol.2009.09.027
复制
发表时间：
2010-06-01
影响因子：
9.8
通讯作者：
Chen, Jong-Dar
中科院分区：
文献类型：
--
作者：
Liu, Pei-Wen;Chang, Tsui-Yen;Chen, Jong-Dar
血清尿酸与代谢综合征之间的正相关性已被报道，但关于台湾成年人血清尿酸与代谢综合征之间的相关性的信息很少。目的。本研究的目的是探讨台湾成年人血清尿酸水平与代谢症候群之间的关系。我们对2085名男性和1557名女性进行了一项横断面研究。所有参与者在2005年1月至2005年12月期间在新光吴和洙纪念医院的一个健康中心接受了健康筛查。根据国家胆固醇教育计划成人治疗组III标准定义代谢综合征。结果表明，高尿酸血症与高尿酸血症、低高密度脂蛋白胆固醇水平和高血压的风险增加显著相关。男性尿酸水平第四个四分位数的代谢综合征风险显著高于第一个四分位数（比值比[OR]，1.50; 95%可信区间[CI]，1.06-2.14）和女性尿酸水平第四个四分位数的代谢综合征风险显著高于第一个四分位数（OR，2.33; 95% CI，1.39-3.93）。此外，男性尿酸水平与高血糖呈负相关。与尿酸最低四分位数相比，尿酸第二、第三和第四分位数的高血糖OR分别为0.69（95% CI，0.46-1.03）、0.55（95% CI，0.37-0.83）和0.45（95% CI，0.29-0.69）。结果表明。在台湾成人中，血清尿酸水平与代谢症候群呈正相关，而尿酸与空腹血糖呈负相关。(C)2010年爱思唯尔公司All rights reserved.
A positive association between serum uric acid and metabolic syndrome has been reported, but little information is available about the association between scrum uric acid and metabolic syndrome in Taiwanese adults. The purpose. of this study was to investigate the association between serum uric acid levels and metabolic syndrome in Taiwanese adults. We performed a cross-sectional study of 2085 men and 1557 women. All of the participants underwent a health screening during the period from January 2005 to December 2005 at a health center of the Shin Kong Wu Ho-Su Memorial Hospital. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. The results showed that hyperuricemia was significantly associated with increased risk for hypertriglyceridemia, low high-density lipoprotein cholesterol level, and high blood pressure in men and women. The risk of metabolic syndrome was significantly higher in the fourth quartile than in the first quartile of uric acid level in men (odds ratio [OR], 1.50; 95% confidence interval [Cl], 1.06-2.14) and women (OR, 2.33; 95% Cl, 1.39-3.93). In addition, uric acid level was inversely associated with hyperglycemia in men. The ORs of hyperglycemia for the second, third, and fourth quartile of uric acid were 0.69 (95% Cl, 0.46-1.03), 0.55 (95% Cl, 0.37-0.83), and 0.45 (95% Cl, 0.29-0.69), respectively, compared with the lowest quartile of uric acid. The results demonstrate that. there is a positive association between serum uric acid levels and metabolic syndrome and an inverse association between uric acid and fasting plasma glucose in Taiwanese adults. (C) 2010 Elsevier Inc. All rights reserved.