Ultrastructural studies on mitochondrial swelling.
Ultrastructural studies on mitochondrial swelling.
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线粒体肿胀的超微结构研究。
DOI：
10.1042/bj1180883
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发表时间：
1970
期刊：
影响因子：
--
通讯作者：
J. Judah
中科院分区：
文献类型：
--
作者：
W. H. Butler;J. Judah
本文研究了高锰酸钾固定后，缬氨霉素、氯化钙和P（i）引起的线粒体肿胀。缬氨霉素诱导快速K（+）内流，基质空间增加，嵴外折，基质材料保存良好。这种肿胀是可逆的，但嵴不完全重新形成，并有一个水泡的外观。在反复的膨胀和收缩循环中，基质材料逐渐损失。氯化钙和P（i）产生基质空间的缓慢溶胀。ATP引起的收缩是部分的，与恢复到原始结构无关。
Mitochondrial swelling induced by valinomycin, calcium chloride and P(i) was studied after potassium permanganate fixation in suspension. Valinomycin induces a rapid K(+) influx, increase of the matrix space and out-folding of the cristae, with good preservation of the matrix material. This swelling is reversible but the cristae do not completely re-form and have a blebbed appearance. On repeated swelling and contraction cycles there is a gradual loss of matrix material. Calcium chloride and P(i) produce a slow swelling of the matrix space. Shrinkage induced by ATP was partial and not associated with return to the original structure.