Expression of S100A Alarmins in Cord Blood Monocytes Is Highly Associated With Chorioamnionitis and Fetal Inflammation in Preterm Infants
Expression of S100A Alarmins in Cord Blood Monocytes Is Highly Associated With Chorioamnionitis and Fetal Inflammation in Preterm Infants
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DOI：
10.3389/fimmu.2020.01194
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发表时间：
2020-06-16
影响因子：
7.3
通讯作者：
Savman, Karin
中科院分区：
文献类型：
--
作者：
Golubinskaya, Veronika;Puttonen, Henri;Savman, Karin
背景：暴露于绒毛膜羊膜炎和胎儿炎症反应的早产儿有新生儿发病率和不良结局的风险。Alarmins S100A8、S100A9和S100A12由髓系细胞表达，与炎症激活和单核细胞调节有关。目的：研究足月健康和早产儿脐血单核细胞中S100A报警蛋白的表达及其与临床表现、炎症标志物和报警蛋白水平的关系，以及单核细胞差异调节基因所识别的通路。方法：脐血CD14+单核细胞分离自正常足月新生儿(n=10)和早产儿(n=10)。
Background:Preterm infants exposed to chorioamnionitis and with a fetal inflammatory response are at risk for neonatal morbidity and adverse outcome. Alarmins S100A8, S100A9, and S100A12 are expressed by myeloid cells and have been associated with inflammatory activation and monocyte modulation. Aim:To study S100A alarmin expression in cord blood monocytes from term healthy and preterm infants and relate results to clinical findings, inflammatory biomarkers and alarmin protein levels, as well as pathways identified by differentially regulated monocyte genes. Methods:Cord blood CD14+ monocytes were isolated from healthy term (n= 10) and preterm infants (