Papular clear cell hyperplasia of the eccrine duct in a diabetic
Papular clear cell hyperplasia of the eccrine duct in a diabetic
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糖尿病患者小汗腺管丘疹性透明细胞增生
DOI：
10.1046/j.1365-2133.1996.d01-952.x
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发表时间：
1996
影响因子：
10.3
通讯作者：
T. Faraggiana
中科院分区：
文献类型：
--
作者：
S. Signoretti;G. Annessi;S. Occhiuto;P. Ruatti;T. Faraggiana
摘要我们报告一位广泛性丘疹病患，其特征是小汗腺分泌部分广泛的透明细胞增生。一名46岁的女性有很长一段时间的弥漫性丘疹病史，这让皮肤看起来像鸡皮疙瘩。她患有严重的糖尿病。丘疹的组织学检查显示明显的透明细胞增生，累及标本中存在的所有分泌单位的分泌管，而不包括分泌卷曲。透明细胞PAS染色阳性，阿尔新蓝染色阴性。超微结构研究证实，透明细胞含有丰富的胞浆内糖原。我们认为糖尿病可能在促进糖原在小汗腺导管中的积聚中起重要作用。我们的病人表现为一种特殊的小汗腺单位紊乱，根据临床病理特征，我们称之为丘疹状透明细胞增生性小汗腺管。
Summary We report a patient with a widespread papular disorder characterized by extensive clear cell hyperplasia of the secretory portion of the eccrine units. A 46‐year‐old woman had a long history of diffuse papules which gave the skin a ‘goose‐flesh’ appearance. She had severe diabetes. Histological examination of a papule showed marked clear cell hyperplasia that involved the secretory duct of all eccrine units present in the specimen sparing the secretory coil. The clear cells were periodic acid‐Schiff (PAS) positive and Alcian blue negative. Ultrastructural study confirmed that the clear cells contained abundant intracytoplasmatic glycogen. We suggest that the diabetic condition may be important in promoting the accumulation of glycogen in the eccrine ducts. Our patient represents a peculiar disorder of the eccrine units that, on the basis of clinicopathological features, we have termed papular clear cell hyperplasia of the eccrine duct