Education, activity, health, blood pressure and apolipoprotein E as predictors of cognitive change in old age: A review
Education, activity, health, blood pressure and apolipoprotein E as predictors of cognitive change in old age: A review
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DOI：
10.1159/000022153
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发表时间：
2000-05-01
期刊：
影响因子：
3.5
通讯作者：
Christensen, H
中科院分区：
文献类型：
--
作者：
Anstey, K;Christensen, H
背景：横断面研究已经确定了许多与老年认知功能相关的健康和生活方式因素。重要的是要知道这些因素是否也预测随着时间的推移认知功能的变化。目的：评估已发表的关于成年后期认知变化的遗传、健康和生活方式预测因素的研究结果。研究方法：回顾了关于教育、健康、血压、活动和载脂蛋白E（APOE）作为认知变化预测因子的研究报告。共有34项研究报告了这些预测因素的数据。研究的平均随访时间为7.68年。结果如下：结果表明，教育，高血压，健康和心血管疾病的客观指标，和APOE与认知变化。关于身体活动对认知变化的影响的结果是不确定的。结论：尽管缺乏一些预测因素的数据，但纵向趋势与老年认知表现预测因素的横截面研究结果基本一致。需要更多的研究来比较预测因素对不同类型认知能力的影响。版权所有（C）2000 S. Karger AG，巴塞尔。
Background: Cross-sectional studies have identified a number of health and lifestyle factors that correlate with cognitive function in old age. It is important to know whether these factors also predict change in cognitive function over time. Objective: To evaluate published findings on genetic, health and lifestyle predictors of cognitive change in late adulthood. Methods: Studies reporting data on education, health, blood pressure, activity and apolipoprotein E (APOE) as predictors of cognitive change were reviewed. A total of 34 studies were identified that reported data on these predictors. The average follow-up period of studies reviewed was 7.68 years. Results: Results showed that education, hypertension, objective indices of health and cardiovascular disease, and APOE were associated with cognitive change. Results regarding the effect of physical activity on cognitive change were inconclusive. Conclusion: Despite the lack of data on some predictors, the longitudinal trends are generally consistent with cross-sectional findings on predictors of cognitive performance in old age. More research is required to compare the influence of predictors on different types of cognitive abilities. Copyright (C) 2000 S. Karger AG, Basel.