Rodent estrous cycle response to incomplete spinal cord injury, surgical interventions, and locomotor training.
Rodent estrous cycle response to incomplete spinal cord injury, surgical interventions, and locomotor training.
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啮齿动物发情周期对不完全脊髓损伤、手术干预和运动训练的反应。
DOI：
10.1037/a0026032
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发表时间：
2011
影响因子：
1.9
通讯作者：
Edgerton,VReggie
中科院分区：
文献类型：
--
作者：
Shah,PrithviK;Song,James;Kim,Samuel;Zhong,Hui;Roy,RolandR;Edgerton,VReggie
雌性大鼠脊髓损伤后的发情周期中断是一种常见现象。然而，这种异常的发情周期是由于脊髓本身的损伤还是由于手术干预引起的一般应激，目前尚不清楚。我们通过对雌性大鼠进行脊髓半切（HX）、将肌电线植入选定的后肢肌肉和/或向脊髓注射示踪染料后测定其发情周期来解决这一问题。由于已知有氧运动可以增强不完全性脊髓损伤啮齿动物运动功能的恢复，我们也确定了运动训练是否对HX后中断的发情周期有积极影响。27只雌性大鼠在HX、肌电图和/或染料注射手术前后，以及HX术后自行恢复或进行运动训练的大鼠，在5-8周内进行动情周期评估。我们的研究结果显示，在HX、肌电图和染料注射手术后，大约76%、46%和50%的大鼠的发情周期被破坏（周期长度为50天）。然而，与肌电图或染料注射手术相比，HX术后周期性被破坏的时间更长。此外，训练HX组的发情周期平均长度比未训练HX组短。这些结果表明，严重脊髓损伤后的发情周期中断是脊髓直接损伤和相关应激的结果。此外，在脊髓HX后早期开始适度的有氧运动可以使发情周期的持续时间恢复正常。（PsycINFO数据库记录(c) 2016 APA，版权所有）
Estrous cycle disruption after spinal cord injury (SCI) in female rats is a common phenomenon. It remains unknown, however, if the aberrant estrous cycle is a result of an injury to the spinal cord itself or due to the general stress associated with surgical interventions. We addressed this issue by determining estrous cyclicality in female rats after a spinal cord hemisection (HX), implantation of EMG wires into selected hind limb muscles, and/or injections of tracer dyes into the spinal cord. Because it is known that aerobic exercise can enhance the recovery of locomotor function in rodents with an incomplete SCI, we also determined if locomotor training positively impacts the disrupted estrous cycle after an HX. Estrous cycle assessments were made during a 5–8 week period in 27 female rats before and after HX, EMG, and/or dye injection surgeries and in HX rats that recovered spontaneously or underwent locomotor training. Our results show that estrous cyclicality was disrupted (cycle length> 5 days) in approximately 76%, 46%, and 50% of the rats after HX, EMG, and dye injection surgeries, respectively. The cyclicality, however, was disrupted for a longer period after HX than after EMG or dye injection surgeries. Furthermore, estrous cycle mean length was shorter in the trained than nontrained HX group. These results suggest that estrous cycle disruption after a major SCI is a consequence of both the direct injury to the spinal cord and to the associated stress. Moreover, moderate aerobic exercise initiated early after a spinal cord HX returns the duration of the estrous cycle toward normal.(PsycINFO Database Record (c) 2016 APA, all rights reserved)