Mathematical models of skin permeability: An overview
Mathematical models of skin permeability: An overview
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DOI：
10.1016/j.ijpharm.2011.02.023
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发表时间：
2011-10-10
影响因子：
5.8
通讯作者：
Roberts, Michael S.
中科院分区：
文献类型：
--
作者：
Mitragotri, Samir;Anissimov, Yuri G.;Roberts, Michael S.
皮肤渗透性的数学模型在包括药物透皮给药预测和工业化学品皮肤暴露评估的各个领域中起着重要作用。在过去的几十年中，已经进行了广泛的研究，以预测皮肤对各种分子的渗透性。这些努力包括发展经验方法，如定量结构-渗透率关系和多孔通道理论，以及建立严格的基于结构的模型。除了建立必要的数学框架来描述这些模型之外，还致力于确定使用这些模型所需的关键参数。本文综述了各种建模方法的优点、局限性和发展前景。(C)2011 Elsevier B. V.保留所有权利。
Mathematical models of skin permeability play an important role in various fields including prediction of transdermal drug delivery and assessment of dermal exposure to industrial chemicals. Extensive research has been performed over the last several decades to yield predictions of skin permeability to various molecules. These efforts include the development of empirical approaches such as quantitative structure-permeability relationships and porous pathway theories as well as the establishment of rigorous structure-based models. In addition to establishing the necessary mathematical framework to describe these models, efforts have also been dedicated to determining the key parameters that are required to use these models. This article provides an overview of various modeling approaches with respect to their advantages, limitations and future prospects. (C) 2011 Elsevier B.V. All rights reserved.