HIV PROTEASE - A NOVEL CHEMOTHERAPEUTIC TARGET FOR AIDS
HIV PROTEASE - A NOVEL CHEMOTHERAPEUTIC TARGET FOR AIDS
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DOI：
10.1021/jm00112a001
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发表时间：
1991-08-01
影响因子：
7.3
通讯作者：
HUFF, JR
中科院分区：
文献类型：
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作者：
HUFF, JR
获得性免疫缺陷综合征(AIDS)的流行传播推动了人们对这一致命疾病的认识和抗击，进行了前所未有的科学和临床努力。艾滋病的病原体已被确定为慢病毒科的一种逆转录病毒。1‘1 2最初被称为HTLV-III或LAV，这种有包膜的单链RNA病毒现在被命名为人类免疫缺陷病毒(HIV)，3，4和两种不同的基因亚型，HIV-1和HIV-2，已经被表征。这种以单核细胞表达表面CD4受体为靶点的病毒感染6-7，最终会对细胞免疫产生深远的影响。随着时间的推移，感染会导致CD4+T淋巴细胞严重耗尽，导致机会性感染、神经和肿瘤疾病，最终导致死亡。对病毒复制至关重要的分子事件的识别使我们能够为潜在的化疗干预选择几种策略。9，其中10个，封锁
The pandemic spread of acquired immunodeficiency syndrome (AIDS) has promoted an unprecedented scien-tific and clinicaleffort tounderstand and combat this lethal disease. The etiological agent of AIDS has been identified as a retrovirus of the Lentiviridae family. 1’1 2 Originally referred to as HTLV-III or LAV, this enveloped, single-stranded RNA virus is now designated human im-munodeficiency virus (HIV), 3, 4 and two genetically distinct subtypes, HIV-1 and HIV-2, have been characterized. 6-7 Infection by the virus, which targetsmonocytes expressing surface CD4 receptors, eventually produces profound de-fects in cell-mediated immunity. 8 9* Over time infection leads to severe depletion of CD4+ T-lymphocytes resulting in opportunistic infections, neurologic and neoplastic disease, and ultimately death. Identification of the mo-lecular events critical to virus replication has enabled the selection of several strategies for potential chemothera-peutic intervention. 9, 10 Among those, blockade of the