EPIDEMIOLOGY OF KAPOSIS SARCOMA IN SWEDEN PRIOR TO THE ACQUIRED IMMUNODEFICIENCY SYNDROME
EPIDEMIOLOGY OF KAPOSIS SARCOMA IN SWEDEN PRIOR TO THE ACQUIRED IMMUNODEFICIENCY SYNDROME
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DOI：
10.1002/ijc.2910420307
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发表时间：
1988-09-15
影响因子：
6.4
通讯作者：
ATTEWELL, R
中科院分区：
文献类型：
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作者：
DICTOR, M;ATTEWELL, R
我们回顾性研究了1958年至1982年瑞典癌症登记处报告的529例卡波西肉瘤（KS），以确定发病率，生存率和比率，以及相关恶性肿瘤的频率和类型。年龄标准化（瑞典人口，1970年）发病率在此期间普遍增加，平均每年每10万人0.27例（男性0.40，女性0.14）。1968-1972年期间，发病率比率（基于5年间隔和相对于最早期）男性为2.06，女性为3.76，而男女发病率的实际峰值出现在1971 - 1974年期间。泊松回归模型表明，在特定年龄的男性发病率模式的一个短暂的转变，相对增加的疾病在年轻的年龄组（p = 0.05），直到1968年至1972年。在研究期间，年龄调整的男性：女性比例从2.9没有显著变化。与一般人群相比，在诊断后10年内存活的男性和女性分别减少了18%和24%。99例（19%）病例有其他原发灶，其中17例为淋巴细胞源性肿瘤。KS患者（尤其是女性）中，增生性恶性肿瘤的发生率是预期的2.5倍（95% CI 1.38，4.37），但其他恶性肿瘤的发生率没有明显增加。由于其他恶性疾病或药物治疗引起的免疫功能障碍是否可以解释KS的流行病学变化是值得怀疑的，KS的流行病学变化在瑞典艾滋病流行前近20年就开始了。
We studied retrospectively 529 cases of Kaposi''s sarcoma (KS) reported to the Swedish Cancer Registry between 1958 and 1982 to determine incidence rates, survival and rate ratios, together with the frequency and types of associated malignancies. The age-standardized (Swedish population 1970) incidence rate generally increased over the time period, with a mean of 0.27 cases per 100,000 population per year (males 0.40, females 0.14). The incidence rate ratio (based on 5-year intervals and relative to the earliest period) reached 2.06 for males and 3.76 for females in the 1968-1972 interval, while the actual peak occurred between 1971 and 1974 for both sexes. Poisson regression modelling suggested a transient shift in the age-specific male incidence rate pattern with a relative increase of the disease in younger age groups (p = 0.05) up to 1968-1972. The age-adjusted male:female ratio did not change significantly from 2.9 during the period of study. In relation to the general population, 18% fewer men and 24% fewer women were alive 10 years after the diagnosis had been made. Ninety-nine (19%) cases had other primaries, of which 17 were neoplasms of lymphocytic origin. Lymphoproliferative malignancy was 2.5 times (95% Cl 1.38, 4.37) more common than expected in patients with KS (in particular in females) but a definite increase in other malignancies was not apparent. It is questionable whether immune dysfunction due to other malignant disease or drug therapy can account for the epidemiologic changes in KS, which began almost 2 decades prior to the AIDS epidemic in Sweden.