Recellularization of decellularized heart valves: Progress toward the tissue-engineered heart valve.
Recellularization of decellularized heart valves: Progress toward the tissue-engineered heart valve.
复制标题
脱细胞心脏瓣膜的覆盖：向组织工程心脏瓣膜迈进。
DOI：
10.1177/2041731417726327
复制
发表时间：
2017-01
影响因子：
8.2
通讯作者：
Converse GL
中科院分区：
文献类型：
--
作者：
VeDepo MC;Detamore MS;Hopkins RA;Converse GL
组织工程心脏瓣膜预示着瓣膜置换领域的新时代。脱细胞心脏瓣膜由于其天然生物活性成分、作为独立植入物的临床相关性以及体内部分再细胞化而作为组织工程心脏瓣膜的支架引起了极大的兴趣。然而，实现组织工程心脏瓣膜仍面临重大挑战：确保表型适当的细胞对整个瓣膜小叶进行一致的再细胞化。许多创造性策略都追求完全的生物瓣膜再细胞化；然而，事实证明，确定最佳的再细胞化方法，包括原位或体外再细胞化以及化学和/或机械调节是很困难的。此外，虽然许多研究都集中在增加瓣膜间质再细胞化的各个参数上，但要想取得成功，可能需要对相互作用的动力学有一个总体的了解。因此，本综述的目的是探索和比较用于组织工程心脏瓣膜脱细胞和随后再细胞化的各种处理策略。
The tissue-engineered heart valve portends a new era in the field of valve replacement. Decellularized heart valves are of great interest as a scaffold for the tissue-engineered heart valve due to their naturally bioactive composition, clinical relevance as a stand-alone implant, and partial recellularization in vivo. However, a significant challenge remains in realizing the tissue-engineered heart valve: assuring consistent recellularization of the entire valve leaflets by phenotypically appropriate cells. Many creative strategies have pursued complete biological valve recellularization; however, identifying the optimal recellularization method, including in situ or in vitro recellularization and chemical and/or mechanical conditioning, has proven difficult. Furthermore, while many studies have focused on individual parameters for increasing valve interstitial recellularization, a general understanding of the interacting dynamics is likely necessary to achieve success. Therefore, the purpose of this review is to explore and compare the various processing strategies used for the decellularization and subsequent recellularization of tissue-engineered heart valves.
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影响因子：
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作者：
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