Differential immunological responses induced by infection with female muscle larvae and newborn larvae of Trichinella pseudospiralis.
Differential immunological responses induced by infection with female muscle larvae and newborn larvae of Trichinella pseudospiralis.
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DOI：
10.1016/j.vetpar.2013.01.059
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发表时间：
2013-05
影响因子：
2.6
通讯作者：
Z. Wu;I. Nagano;K. Asano;M. Liu;Y. Takahashi
中科院分区：
文献类型：
--
作者：
Z. Wu;I. Nagano;K. Asano;M. Liu;Y. Takahashi
旋毛虫感染可调节自身免疫性和变态反应性疾病的免疫应答，从而改善这些疾病。本研究比较了蠕虫和肌幼虫诱导的免疫力。从新生幼虫（NBL）感染中观察到的嗜酸性粒细胞增多症高于成年雌性，而在成年雌性感染中观察到的IgE水平高于NBL诱导的感染。IgG 1对ES抗原的反应在成年女性感染中更为突出。IgG 2对幼虫粗抗原的反应对NBL是突出的。Th 2细胞因子、IL-4细胞因子在成年女性感染后用成人粗抗原和ES再刺激后升高。两种感染均诱导强烈的IFN-γ应答。本研究表明，成年雌蠕虫诱导更强的Th 2反应（IgG 1，IgE和IL-4反应）比NBL。进一步研究参与免疫调节的机制可能有助于确定旋毛虫衍生的分子，负责调节自身免疫性和过敏性疾病。
Trichinella pseudospiralis infection can modulate the immunological response of autoimmune and allergic diseases leading to the amelioration of these diseases. The present study was undertaken to compare immunity induced by adult worms and muscle larvae. Higher eosinophilia was observed from newborn larva (NBL) infection than from adult females while higher levels of IgE were observed in adult female infections over those induced by NBL. The IgG1 response to ES antigen was more prominent in infections with adult females. The IgG2 responses to larval crude antigen were prominent against NBL. The Th2 cytokine, IL-4 cytokine was elevated in adult female infection following re-stimulation with adult crude antigen and ES. Both infections induced strong IFN-γ responses. The present study demonstrates that adult female worms induced stronger Th2 responses (IgG1, IgE and IL-4 responses) than NBL. Further examination of the mechanisms involved in immune modulation may be helpful for identifying Trichinella-derived molecules responsible for regulating autoimmune and allergic diseases.