Do large, simple trials have a place in the evaluation of AIDS therapies?
Do large, simple trials have a place in the evaluation of AIDS therapies?
复制标题
大型、简单的试验在艾滋病治疗的评估中占有一席之地吗？
作者：
S. Ellenberg
招募大量患者且只需收集相对少量基线数据和随访数据的试验对评估艾滋病治疗方法有用吗？广泛开展大型、简单的试验（尤其是那些侧重于优化现有药物剂量方案的试验）是否能达到双重目的，即回答重要的患者管理问题以及改善贫困人群获得已上市治疗方法的途径，这似乎值得考虑。
Would trials enrolling large numbers of patients and that would require the collection of a relatively small amount of baseline and follow-up data be useful in evaluating treatments for AIDS? It seems worth considering whether widely available large, simple trials, especially those focused on optimizing dosage regimens of existing drugs, could serve the dual purpose of answering important patient management questions and improving the access of indigent populations to marketed therapies.