Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks.
Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks.
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DOI：
10.3390/ph10010027
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发表时间：
2017-03-05
期刊：
影响因子：
--
通讯作者：
Litchfield DW
中科院分区：
文献类型：
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作者：
Nuñez de Villavicencio-Diaz T;Rabalski AJ;Litchfield DW
蛋白激酶CK2是一个小的蛋白激酶家族，它与一系列不断扩大的生物过程有关。虽然人们普遍认为CK2是许多基本细胞过程的调节参与者，但CK2通常被认为是一种组成活性酶，这就提出了关于它如何在复杂控制的细胞过程中发挥调节作用的问题。为了解决这个明显的矛盾，我们对已发表的文献进行了系统的分析，使用文本挖掘和蛋白质组数据库的挖掘，以及涉及CK2的网络的计算组装。这些分析强化了CK2参与多种生物过程的概念，也揭示了CK2磷酸化和其他翻译后修饰之间广泛的相互作用。CK2和其他翻译后修饰之间的相互作用表明，CK2在协调细胞事件中确实起着复杂的作用。在这方面，CK2对特定底物的磷酸化可以通过其他翻译后修饰来调节，CK2也可能在调节其他翻译后修饰中发挥作用。总的来说，这些观察结果表明CK2的作用与调节细胞网络的其他成分精确协调。
Protein kinase CK2 is a small family of protein kinases that has been implicated in an expanding array of biological processes. While it is widely accepted that CK2 is a regulatory participant in a multitude of fundamental cellular processes, CK2 is often considered to be a constitutively active enzyme which raises questions about how it can be a regulatory participant in intricately controlled cellular processes. To resolve this apparent paradox, we have performed a systematic analysis of the published literature using text mining as well as mining of proteomic databases together with computational assembly of networks that involve CK2. These analyses reinforce the notion that CK2 is involved in a broad variety of biological processes and also reveal an extensive interplay between CK2 phosphorylation and other post-translational modifications. The interplay between CK2 and other post-translational modifications suggests that CK2 does have intricate roles in orchestrating cellular events. In this respect, phosphorylation of specific substrates by CK2 could be regulated by other post-translational modifications and CK2 could also have roles in modulating other post-translational modifications. Collectively, these observations suggest that the actions of CK2 are precisely coordinated with other constituents of regulatory cellular networks.