Direct comparison of FP-CIT SPECT and F-DOPA PET in patients with Parkinson's disease and healthy controls
Direct comparison of FP-CIT SPECT and F-DOPA PET in patients with Parkinson's disease and healthy controls
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DOI：
10.1007/s00259-008-0989-5
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发表时间：
2009-03-01
影响因子：
9.1
通讯作者：
Leenders, K. L.
中科院分区：
文献类型：
--
作者：
Eshuis, S. A.;Jager, P. L.;Leenders, K. L.
根据临床诊断帕金森病 (PD) 可能很困难，尤其是在疾病的早期阶段。 F-DOPA PET 和 FP-CIT SPECT 扫描能够以不同的方式确定突触前多巴胺能活动。本研究的目的是确定并比较两种方法在同一组 PD 患者和健康对照中检测纹状体多巴胺能缺陷的敏感性和特异性。运动障碍专家招募了 11 名早期 PD 患者和 17 名晚期 PD 患者。患者接受了 FP-CIT SPECT 扫描和 F-DOPA PET 扫描。此外，对 20 名健康对照者进行了 10 次 FP-CIT SPECT 扫描或 10 次 F-DOPA PET 扫描。使用具有感兴趣区域的模板对大脑中尾状核、壳核和参考区域的示踪剂活动进行采样。结果参数是纹状体枕骨比率（SOR）。正常 SOR 值是在对照中确定的。计算了两种扫描方法的敏感性和特异性。FP-CIT SPECT 和 F-DOPA PET 扫描都能够区分 PD 患者和健康对照。对于疾病的早期阶段，对侧纹状体和壳核摄取 FP-CIT 和 F-DOPA 的敏感性和特异性为 100%。仅考虑尾状核摄取时，FP-CIT 和 F-DOPA 的特异性分别为 100% 和 90%，而两种扫描技术的敏感性均为 91%。 FP-CIT SPECT 和 F-DOPA PET 扫描均能够诊断 PD 早期的突触前多巴胺能缺陷，具有出色的敏感性和特异性。
Diagnosing Parkinson's disease (PD) on clinical grounds may be difficult, especially in the early stages of the disease. F-DOPA PET and FP-CIT SPECT scans are able to determine presynaptic dopaminergic activity in different ways. The aim of this study was to determine and compare the sensitivity and specificity of the two methods in the detection of striatal dopaminergic deficits in the same cohort of PD patients and healthy controls.Movement disorder specialists recruited 11 patients with early-stage PD and 17 patients with advanced PD. The patients underwent both an FP-CIT SPECT scan and an F-DOPA PET scan. In addition, 10 FP-CIT SPECT scans or 10 F-DOPA PET scans were performed in 20 healthy controls. A template with regions of interest was used to sample tracer activity of the caudate, putamen and a reference region in the brain. The outcome parameter was the striatooccipital ratio (SOR). Normal SOR values were determined in the controls. The sensitivity and specificity of both scanning methods were calculated.FP-CIT SPECT and F-DOPA PET scans were both able to discriminate PD patients from healthy controls. For the early phases of the disease, sensitivity and specificity of the contralateral striatal and putaminal uptake of FP-CIT and F-DOPA was 100%. When only caudate uptake was considered, the specificities were 100% and 90% for FP-CIT and F-DOPA, respectively, while the sensitivity was 91% for both scanning techniques.FP-CIT SPECT and F-DOPA PET scans are both able to diagnose presynaptic dopaminergic deficits in early phases of PD with excellent sensitivity and specificity.