Chronic intracerebroventricular infusion of MCH causes obesity in mice
Chronic intracerebroventricular infusion of MCH causes obesity in mice
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DOI：
10.1152/ajpendo.00350.2002
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发表时间：
2003-03-01
影响因子：
5.1
通讯作者：
Kanatani, A
中科院分区：
文献类型：
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作者：
Gomori, A;Ishihara, A;Kanatani, A
黑色素浓缩激素(MCH)是一种定位于下丘脑外侧区的环状氨基酸神经肽。虽然MCH被认为是摄食行为的重要调节因子，但这种多肽在体重控制中的作用尚不清楚。为了研究MCH在肥胖发展中的作用，我们评估了长期脑室注射MCH对喂饲常规或中等高脂(MHF)饲料的C57BL/6J小鼠的影响。脑室内注射MCH(每天10杯，连续14天)可使正常饮食的小鼠体重略有增加，但显著增加。在MHF饮食喂养的小鼠中，MCH更明显地增加了体重，并伴随着持续的吞噬作用，脂肪和肝脏重量显著增加。喂食MHF饮食的服用MCH的小鼠的血糖、胰岛素和瘦素水平也有所升高。这些结果表明，大脑MCH系统的慢性刺激会导致小鼠肥胖，并暗示MCH可能在能量平衡中发挥重要作用。
Melanin-concentrating hormone (MCH) is a cyclic amino acid neuropeptide localized in the lateral hypothalamus. Although MCH is thought to be an important regulator of feeding behavior, the involvement of this peptide in body weight control has been unclear. To examine the role of MCH in the development of obesity, we assessed the effect of chronic intracerebroventricular infusion of MCH in C57BL/6J mice that were fed with regular or moderately high-fat (MHF) diets. Intracerebroventricular infusion of MCH (10 mug/day for 14 days) caused a slight but significant increase in body weight in mice maintained on the regular diet. In the MHF diet-fed mice, MCH more clearly increased the body weight accompanied by a sustained hyperphagia and significant increase in fat and liver weights. Plasma glucose, insulin, and leptin levels were also increased in the MCH-treated mice fed the MHF diet. These results suggest that; chronic stimulation of the brain MCH system causes obesity in mice and imply that MCH may have a major role in energy homeostasis.