Qualitative and quantitative detection of urinary human complement factor H-related protein (BTA stat and BTA TRAK) and fragments of cytokeratins 8, 18 (UBC rapid and UBCIRMA) as markers for transitional cell carcinoma of the bladder
Qualitative and quantitative detection of urinary human complement factor H-related protein (BTA stat and BTA TRAK) and fragments of cytokeratins 8, 18 (UBC rapid and UBCIRMA) as markers for transitional cell carcinoma of the bladder
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DOI：
10.1016/s0302-2838(01)00015-x
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发表时间：
2002-01-01
期刊：
影响因子：
23.4
通讯作者：
Zima, T
中科院分区：
文献类型：
--
作者：
Babjuk, M;Kostírová, M;Zima, T
目的：探讨BTA stat、BTA TRAK、UBC Rapid、UBC IRMA及尿脱落细胞学检查在膀胱移行细胞癌（TCC）诊断中的作用。研究包括78例膀胱TCC患者（A组），62例在检查时无肿瘤复发的膀胱TCC病史对照组（B）、其他泌尿系恶性肿瘤患者20例（C）、非恶性泌尿系疾病患者38例（D）、泌尿系感染患者10例（E）和健康志愿者10例（F）。除R组外，其余各组均在膀胱镜检查或膀胱镜检查前收集尿液。BTA stat检测膀胱癌的特异性和敏感性分别为87.1%和74.4%，UBC Rapid检测膀胱癌的特异性和敏感性分别为79.3%和48.7%，细胞学检测膀胱癌的特异性和敏感性分别为100%和33.3%，BTA TRAK检测膀胱癌的特异性和敏感性分别为72.6%和75.6%，结论：BTA stat和BTATRAK检测对膀胱移行细胞癌的诊断价值优于UBC Rapid、UBC IRMA和尿脱落细胞学检查，且具有上级的临床应用价值。然而，在日常实践中，细胞学检查仍然是膀胱镜检查的最佳辅助手段，因为其在Tis中的高灵敏度和100%的特异性。膀胱镜检查不能被任何评价的方法所取代。(C)2002 Elsevier Science B.V保留所有权利。
Objective: To evaluate the role of BTA stat, BTA TRAK, UBC Rapid, UBC IRMA and voided urinary cytology in the detection of bladder transitional cell carcinoma (TCC).Methods: The study included 78 patients with TCC of the bladder (group A), 62 patients with a history of bladder TCC without tumor recurrence at the time of examination (B, control group), 20 patients with other malignancy of the urinary tract (C), 38 patients with non-malignant urinary tract diseases (D), 10 patients with urinary tract infection (E) and 10 healthy volunteers (F). Except in group R voided urine was collected before cystoscopy or cystectomy.Results: The specificity and sensitivity in bladder cancer detection were 87.1 and 74.4%, respectively with BTA stat, 79.3 and 48.7%, respectively with UBC Rapid, 100 and 33.3%, respectively with cytology, 72.6 and 75.6%, respectively with BTA TRAK, 64.5 and 70.5%, respectively with UBC IRMA.Conclusions: The BTA stat and BTATRAK tests are superior to UBC Rapid, UBC IRMA and urinary cytology in detection of bladder TCC. In daily practice however cytology remains the best adjunct to cystoscopy because of its high sensitivity in Tis and 100% specificity. Cystoscopy cannot be replaced by any of evaluated methods. (C) 2002 Elsevier Science B.V All rights reserved.