DEXTRAN HYDROGELS FOR COLON-SPECIFIC DRUG-DELIVERY
DEXTRAN HYDROGELS FOR COLON-SPECIFIC DRUG-DELIVERY
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DOI：
10.1016/0168-3659(95)00049-e
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发表时间：
1995-09-01
影响因子：
10.8
通讯作者：
BRONDSTED, H
中科院分区：
文献类型：
--
作者：
HOVGAARD, L;BRONDSTED, H
基于与二异氰酸酯交联的葡聚糖的新型水凝胶已被提议用于结肠特异性药物递送。水凝胶的特征在于溶胀平衡度和机械强度。已经使用葡聚糖酶在体外、大鼠体内和人类发酵模型中研究了水凝胶的降解。研究发现，通过改变水凝胶的化学组成，可以控制溶胀的平衡度、机械强度和可降解性。葡聚糖水凝胶在大鼠盲肠体内降解，但在胃中不降解。此外，葡聚糖水凝胶在人结肠发酵模型中被降解，表明葡聚糖酶确实存在于人结肠内容物中。最后，评估了水凝胶中氢化可的松的释放。发现它取决于释放介质中葡聚糖酶的存在。结果表明，葡聚糖水凝胶有望作为结肠特异性药物递送的药物载体。
Novel hydrogels based on dextran crosslinked with diisocyanate have been proposed for colon-specific drug delivery. The hydrogels have been characterized by equilibrium degree of swelling and mechanical strength. Degradation of the hydrogels has been studied in vitro using dextranase, in vivo in rats and in a human fermentation model. It was found that by changing the chemical composition of the hydrogels it is possible to control the equilibrium degree of swelling, mechanical strength and degradability. The dextran hydrogels were degraded in vivo in the cecum of rats but not in the stomach. Furthermore, the dextran hydrogels were degraded in a human colonic fermentation model, indicating that dextranases are indeed present in human colonic contents. Finally, release of hydrocortisone from the hydrogels was evaluated. It was found to depend on the presence of dextranases in the release medium. The results suggest that the dextran hydrogels are promising as drug carriers for colon specific drug delivery.