Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation.
Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation.
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儿童逆境增强了后期护理应力对端粒长度和炎症的影响。
DOI：
10.1097/psy.0b013e31820573b6
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发表时间：
2011-01
影响因子：
3.3
通讯作者：
Glaser R
中科院分区：
文献类型：
--
作者：
Kiecolt-Glaser JK;Gouin JP;Weng NP;Malarkey WB;Beversdorf DQ;Glaser R
此前关于儿童虐待和其他逆境对身体健康影响的研究都是基于年轻人或中年成年人的数据。这项研究解决了以下问题：童年虐待和其他逆境是否会对晚年的炎症和细胞衰老产生持久的、可检测的后果，以及其影响是否大到足以超越主要的慢性压力源——痴呆症家庭照顾的影响。在这个由 132 名健康老年人（平均年龄 = 69.70，SD = 10.14）组成的社区样本中，包括 58 名痴呆症家庭照顾者和 74 名非照顾者，对血液样本进行了白细胞介素 6 (IL-6)、肿瘤坏死因子-α (TNF-α) 和端粒长度（衡量细胞衰老的指标）的分析。抑郁症状通过流行病学研究中心抑郁量表（CES-D）进行评估。在控制了年龄、看护状况、性别、体重指数、运动和睡眠后，与没有逆境的情况相比，多种童年逆境的存在与 IL-6 升高（0.37 ± 0.03 与 0.44 ± 03 log10 pg/mL）和端粒较短（6.51 ± .17 与 5.87 ± .20 Kb）相关。端粒差异可能会导致寿命差异 7 至 15 年。虐待与 IL-6 和 TNF-α 水平升高有关，对于 TNF-α，与对照组相比，看护者的这种关系被放大。此外，虐待和照顾状况与较高水平的抑郁症状显着且独立相关。童年时期的不良事件与老年人的持续脆弱性有关，从而增强了慢性压力源的影响。童年的不幸给他留下了很长的阴影。
Previous research on the physical health consequences of childhood abuse and other adversities has been based on data from young or middle-aged adults. This study addressed the question of whether childhood abuse and other adversities have lasting, detectable consequences for inflammation and cell aging late in life, and whether the effects are large enough to be discernible beyond that of a major chronic stressor, dementia family caregiving. In this community sample of 132 healthy older adults (mean age = 69.70, SD=10.14), including 58 dementia family caregivers and 74 noncaregivers, blood samples were analyzed for interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), and telomere length, a measure of cell aging. Depressive symptoms were assessed by the Center for Epidemiological Studies Depression Scale (CES-D). After controlling for age, caregiving status, gender, body mass index, exercise, and sleep, the presence of multiple childhood adversities was related to both heightened IL-6 (.37 ± .03 vs. .44 ± .03 log10 pg/mL) and shorter telomeres (6.51 ± .17 vs. 5.87 ± .20 Kb), compared to the absence of adversity; the telomere difference could translate into a 7–15 year difference in lifespan. Abuse was associated with heightened IL-6 and TNF-α levels, and, for TNF-α, this relationship was magnified in caregivers compared to controls. Moreover, abuse and caregiving status were significantly and independently associated with higher levels of depressive symptoms. Adverse childhood events are related to continued vulnerability among older adults, enhancing the impact of chronic stressors. Childhood adversities cast a very long shadow.