Evidence of a rare gene for low systolic blood pressure in the Framingham Heart Study.
Evidence of a rare gene for low systolic blood pressure in the Framingham Heart Study.
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弗雷明汉心脏研究中存在一种导致低收缩压的罕见基因的证据。
DOI：
10.1159/000153936
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发表时间：
1990
期刊：
影响因子：
1.8
通讯作者：
Kannel,WB
中科院分区：
文献类型：
--
作者：
Carter,CL;Kannel,WB
男性和女性冠心病的一个主要危险因素是收缩压（SBP）升高。我们使用分离分析程序POINTER对来自Frachial cohort-后代研究的1,141个家庭的年龄、性别调整和转换的收缩压数据进行分离分析。假设检验的结果表明：（1）这些数据与家族传播一致;（2）有证据表明低SBP的一个罕见的主效基因（基因频率q = 0.02）传播;（3）SBP的大部分可传播成分可归因于多基因背景（H=0.31）。
A major risk factor for coronary heart disease in both men and women is elevated systolic blood pressure (SBP). We performed segregation analysis on age, sex-adjusted, and transformed systolic blood pressure data on 1,141 families from the Framingham cohort-offspring study using the segregation analysis program POINTER. The results of hypothesis testing revealed: (1) these data are consistent with familial transmission; (2) there is evidence for the transmission of a rare, major gene for low SBP with a gene frequency of q = 0.02; and (3) most of the transmissible component to SBP can be attributed to the polygenic background with H=0.31.