HORMONAL RESPONSES TO ANALGESIC NITROUS-OXIDE IN MAN
HORMONAL RESPONSES TO ANALGESIC NITROUS-OXIDE IN MAN
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DOI：
10.1055/s-2007-1010939
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发表时间：
1988-12-01
影响因子：
2.2
通讯作者：
SUSANI, E
中科院分区：
文献类型：
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作者：
GILLMAN, MA;KATZEFF, I;SUSANI, E
镇痛浓度的一氧化二氮给药6名健康男性受试者，并测定血液样本的催乳素，促肾上腺皮质激素，促卵泡激素，促黄体生成激素，生长激素，皮质醇和甲状腺激素。镇痛一氧化二氮（平均浓度= 48.8%）产生催乳素和皮质醇抑郁症的统计学显着升高，而没有产生统计学显着变化的其他激素测定。催乳素的增加和皮质醇水平的降低与服用阿片类药物引起的激素变化相似。我们也证实了其他研究人员的发现，即皮质醇水平可能并不总是与ACTH水平相关。
Analgesic concentrations of nitrous oxide were administered to 6 healthy male subjects, and blood samples were assayed for prolactin, ACTH, follicle stimulating hormone, luteinising hormone, growth hormone, cortisol and thyroid hormones. Analgesic nitrous oxide (mean concentration= 48.8%) produced statistically significant elevation of prolactin and depression of cortisol whilst not producing statistically significant changes in the other hormones assayed. The increase in prolactin and decrease in cortisol levels are similar to the hormonal changes associated with administration of opioids in man. We have also confirmed the findings of other workers that cortisol levels may not always be correlated with ACTH levels.