Cation-induced shape programming and morphing in protein-based hydrogels
Cation-induced shape programming and morphing in protein-based hydrogels
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DOI：
10.1126/sciadv.aba6112
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发表时间：
2020-04-01
期刊：
影响因子：
13.6
通讯作者：
Popa, Ionel
中科院分区：
文献类型：
--
作者：
Khoury, Luai R.;Slawinski, Marina;Popa, Ionel
能够记住临时形状并对刺激做出反应的智能材料有可能彻底改变医学和机器人技术。在这里，我们介绍了一种创新的方法来编程蛋白质水凝胶，并在室温下诱导水溶液中的形状变化。我们使用由血清白蛋白制成的水凝胶来展示我们的方法，血清白蛋白是血浆中最丰富的蛋白质，其以圆柱形或花形合成。然后将这些凝胶分别编程为弹簧或环形。编程是通过一个显着的变化，刚度（高达17倍），诱导的吸附Zn2+或Cu2+阳离子。我们表明，这些编程的生物材料可以变形回原来的形状，因为阳离子扩散到水凝胶材料之外。这里展示的方法代表了一种创新的策略，以编程蛋白质为基础的水凝胶作为致动器。
Smart materials that are capable of memorizing a temporary shape, and morph in response to a stimulus, have the potential to revolutionize medicine and robotics. Here, we introduce an innovative method to program protein hydrogels and to induce shape changes in aqueous solutions at room temperature. We demonstrate our approach using hydrogels made from serum albumin, the most abundant protein in the blood plasma, which are synthesized in a cylindrical or flower shape. These gels are then programmed into a spring or a ring shape, respectively. The programming is performed through a marked change in stiffness (of up to 17-fold), induced by adsorption of Zn2+ or Cu2+ cations. We show that these programmed biomaterials can then morph back into their original shape, as the cations diffuse outside the hydrogel material. The approach demonstrated here represents an innovative strategy to program protein-based hydrogels to behave as actuators.