BACTERIOLOGY OF LOWER RESPIRATORY-TRACT AS DETERMINED BY FIBEROPTIC BRONCHOSCOPY AND TRANSTRACHEAL ASPIRATION
BACTERIOLOGY OF LOWER RESPIRATORY-TRACT AS DETERMINED BY FIBEROPTIC BRONCHOSCOPY AND TRANSTRACHEAL ASPIRATION
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DOI：
10.1093/infdis/134.5.428
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发表时间：
1976-01-01
影响因子：
6.4
通讯作者：
HOEPRICH, PD
中科院分区：
文献类型：
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作者：
JORDAN, GW;WONG, GA;HOEPRICH, PD
为评价纤维支气管镜检查（FB）所得气管支气管分泌物和渗出液（TBSE）培养的有效性，对9例健康志愿者和8例患者的痰液和TBSE进行了FB和11例患者经气管抽吸（TA）所得的需氧酸和厌氧植物群的比较。正常志愿者产生的需氧菌和厌氧菌的数量通常< 104.5菌落形成单位（cfu）/ml的TBSE获得FB。在慢性支气管炎患者的15份标本中，TA检出需氧菌42株（104 ~ 105.5cfu/ml），厌氧菌10株（通常< 104 cfu/ml）。低水平污染（≤104 cfu/ml）与口腔植物群的菌落总数在FB获得的TBSE中明显常见。一个潜在的病原体在数量. 105 cfu/ml可能具有病因学意义，特别是如果从肺局部的脓性引流物中回收。在无法进行定量细菌学的情况下，通过TA获得的TBSE将最可靠地反映肺中存在的细菌植物群。
For assessment of the validity of cultures of tracheobronchial secretions and exudates (TBSE) obtained by fiber-optic bronchoscopy [FB], the aerobic acid and anaerobic flora of expectorated saliva and TBSE obtained by FB from 9 healthy volunteers and 8 patients were compared with those obtained by transtracheal aspiration [TA] from 11 patients (from whom TBSE were obtained by FB). Normal volunteers yielded aerobic and anaerobic bacteria in amounts usually < 104.5 colony-forming units (cfu)/ml in TBSE obtained by FB. In patients with chronic bronchitis, 42 isolates of aerobic bacteria (104-105.5 cfu/ml) and only 10 isolates of anaerobes (usually < 104 cfu/ml) were recovered from 15 samples obtained by TA. Low-level contamination (.ltoreq. 104 cfu/ml) with oral flora is apparently common in TBSE obtained by FB. A single potential pathogen in numbers of .gtoreq. 105 cfu/ml may be of etiologic significance, particularly if recovered from purulent drainage material from a localized portion of the lung. Under circumstances in which quantitative bacteriology cannot be done, TBSE obtained by TA will most reliably reflect the bacterial flora present in the lung.