Acute Liver Injury in Patients Hospitalized with COVID-19.
Acute Liver Injury in Patients Hospitalized with COVID-19.
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DOI：
10.1007/s10620-021-07230-9
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发表时间：
2022-08
影响因子：
3.1
通讯作者：
North American Alliance for the Study of Digestive Manifestation of COVID-19*
中科院分区：
文献类型：
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作者：
Sobotka LA;Esteban J;Volk ML;Elmunzer BJ;Rockey DC;North American Alliance for the Study of Digestive Manifestation of COVID-19*
The prevalence and significance of acute liver injury in patients with COVID-19 are poorly characterized. Patients with confirmed COVID-19 who were hospitalized in geographically diverse medical centers in North America were included. Demographics, symptoms, laboratory data results, and outcomes were recorded. Linear and logistic regression identified factors associated with liver injury, in-hospital mortality, and length of stay (LOS). Among 1555 patients in the cohort, most (74%) had an elevated alanine aminotransferase (ALT) during hospitalization, which was very severe (> 20 × upper limit of normal [ULN]) in 3%. Severe acute liver injury (ALI) was uncommon, occurring in 0.1% on admission and 2% during hospitalization. No patient developed acute liver failure (ALF). Higher ALT was associated with leukocytosis (per mL3) (β 10.0, 95% confidence interval (CI) 6.7–12.6, p < 0.001) and vasopressors use (β 80.2, 95%CI 21.5–138.8, p = 0.007). In-hospital mortality was associated with ALT > 20 × ULN (unadjusted OR 6.0, 95%CI 3.1–11.5, p < 0.001), ALP > 3 × ULN (unadjusted OR 4.4, 95%CI 2.5–7.7, p < 0.001), and severe ALI (unadjusted OR 6.8, 95%CI 3.0–15.3, p < 0.001) but lost significance after adjusting for covariates related to severe COVID-19 and hemodynamic instability. Elevated ALP and ALT were associated with longer LOS, admission to intensive care, mechanical ventilation, vasopressor use, and extracorporeal membrane oxygenation use (p < 0.001). Transaminase elevation is common in hospitalized patients with COVID-19. Severe ALI is rare, and ALF may not be a complication of COVID-19. Extreme elevations in liver enzymes appear to be associated with mortality and longer LOS due to more severe systemic disease rather than SARS-CoV-2-related hepatitis. The online version contains supplementary material available at 10.1007/s10620-021-07230-9.
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影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
9.6
作者：
Sarkar S;Rapista N;Jean LG
通讯作者：
Jean LG
影响因子：
3.1
作者：
Gonzalez H;Imam Z;Wong R;Li J;Lu M;Trudeau S;Gordon S;Imam M;Gish R
通讯作者：
Gish R
DOI：
10.1016/j.cgh.2020.09.041
发表时间：
2021-07
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
--
作者：
Elmunzer BJ;Spitzer RL;Foster LD;Merchant AA;Howard EF;Patel VA;West MK;Qayed E;Nustas R;Zakaria A;Piper MS;Taylor JR;Jaza L;Forbes N;Chau M;Lara LF;Papachristou GI;Volk ML;Hilson LG;Zhou S;Kushnir VM;Lenyo AM;McLeod CG;Amin S;Kuftinec GN;Yadav D;Fox C;Kolb JM;Pawa S;Pawa R;Canakis A;Huang C;Jamil LH;Aneese AM;Glamour BK;Smith ZL;Hanley KA;Wood J;Patel HK;Shah JN;Agarunov E;Sethi A;Fogel EL;McNulty G;Haseeb A;Trieu JA;Dixon RE;Yang JY;Mendelsohn RB;Calo D;Aroniadis OC;LaComb JF;Scheiman JM;Sauer BG;Dang DT;Piraka CR;Shah ED;Pohl H;Tierney WM;Mitchell S;Condon A;Lenhart A;Dua KS;Kanagala VS;Kamal A;Singh VK;Pinto-Sanchez MI;Hutchinson JM;Kwon RS;Korsnes SJ;Singh H;Solati Z;Willingham FF;Yachimski PS;Conwell DL;Mosier E;Azab M;Patel A;Buxbaum J;Wani S;Chak A;Hosmer AE;Keswani RN;DiMaio CJ;Bronze MS;Muthusamy R;Canto MI;Gjeorgjievski VM;Imam Z;Odish F;Edhi AI;Orosey M;Tiwari A;Patwardhan S;Brown NG;Patel AA;Ordiah CO;Sloan IP;Cruz L;Koza CL;Okafor U;Hollander T;Furey N;Reykhart O;Zbib NH;Damianos JA;Esteban J;Hajidiacos N;Saul M;Mays M;Anderson G;Wood K;Mathews L;Diakova G;Caisse M;Wakefield L;Nitchie H;Waljee AK;Tang W;Zhang Y;Zhu J;Deshpande AR;Rockey DC;Alford TB;Durkalski V;North American Alliance for the Study of Digestive Manifestations of COVID-19
通讯作者：
North American Alliance for the Study of Digestive Manifestations of COVID-19
DOI：
10.7759/cureus.10045
发表时间：
2020-08-26
期刊：
Cureus
影响因子：
--
作者：
Gurala D;Al Moussawi H;Philipose J;Abergel JR
通讯作者：
Abergel JR