Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier.
Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier.
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DOI：
10.1016/j.trsl.2021.06.001
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Chang EB
中科院分区：
文献类型：
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作者：
Liu CY;Cham CM;Chang EB
许多慢性炎症性疾病被广泛归类为炎症性肠病（IBD）的患者现在有多种免疫调节疗法可供他们使用。尽管有这些最近的医学进步，对大多数患者来说，疾病的完全持续缓解仍然是难以捉摸的。损伤肠黏膜的完全愈合是所有治疗的首要目标。实现这一目标不仅需要减少异常的免疫反应，还需要上皮细胞的伤口愈合。目前还没有批准的治疗方法直接针对上皮细胞。在IBD中，上皮修复受损，通常有助于重建宿主和微生物组之间的稳态屏障。在这篇综述中，我们总结了上皮性伤口愈合是一种重要但不发达的IBD治疗方式的证据。我们强调了三种有希望开发一类新的上皮靶向治疗的一般方法：上皮干细胞，细胞因子和微生物组工程。我们还提供了一些必须克服的挑战，上皮修复治疗杠杆的坦率讨论。该领域协同开发针对上皮性伤口愈合的新疗法，将为患者提供一种改变游戏规则的补充药物，并可能显著改善结果。
Patients with one of the many chronic inflammatory disorders broadly classified as inflammatory bowel disease (IBD) now have a diverse set of immunomodulatory therapies at their disposal. Despite these recent medical advances, complete sustained remission of disease remains elusive for most patients. The full healing of the damaged intestinal mucosa is the primary goal of all therapies. Achieving this requires not just a reduction of the aberrant immunological response, but also wound healing of the epithelium. No currently approved therapy directly targets the epithelium. Epithelial repair is compromised in IBD and normally facilitates re-establishment of the homeostatic barrier between the host and the microbiome. In this review, we summarize the evidence that epithelial wound healing represents an important yet underdeveloped therapeutic modality for IBD. We highlight three general approaches that are promising for developing a new class of epithelium-targeted therapies: epithelial stem cells, cytokines, and microbiome engineering. We also provide a frank discussion of some of the challenges that must be overcome for epithelial repair to be therapeutically leveraged. A concerted approach by the field to develop new therapies targeting epithelial wound healing will offer patients a game-changing, complementary class of medications and could dramatically improve outcomes.
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DOI：
10.1126/science.aay7367
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
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期刊：
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DOI：
10.1084/jem.20151563
发表时间：
2016-08-22
期刊：
The Journal of experimental medicine
影响因子：
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作者：
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影响因子：
64.8
作者：
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通讯作者：
Winton, Douglas J.
影响因子：
8
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