ESTROGEN AND PROGESTERONE-RECEPTOR CONTENT AS A PROGNOSTIC FACTOR IN ADVANCED EPITHELIAL OVARIAN-CARCINOMA
ESTROGEN AND PROGESTERONE-RECEPTOR CONTENT AS A PROGNOSTIC FACTOR IN ADVANCED EPITHELIAL OVARIAN-CARCINOMA
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DOI：
10.1111/j.1471-0528.1990.tb16243.x
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发表时间：
1990-08-01
期刊：
影响因子：
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通讯作者：
SALZER, H
中科院分区：
文献类型：
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作者：
SEVELDA, P;DENISON, U;SALZER, H
对179例卵巢上皮性癌组织中雌激素受体(ER)和孕激素受体(PGR)水平与临床分期、组织学类型、组织学分级、年龄、腹水和术后残留肿瘤的关系进行了研究。激素受体含量测定采用DCC法，受体值大于9fmol/mg蛋白为阳性。术后化疗反应与PGR含量显著相关(PGR阳性组有效率为80%，阴性组仅为61%)。COX比例风险回归模型确定组织学分级、残留肿瘤、年龄和PGR含量是影响晚期上皮性卵巢癌患者生存的独立预后因素。PGR含量对术后残留肿瘤肿块患者的预后有特别显著的相关性。直径2厘米。在这组患者中，PGR阳性患者的两年存活率为83%，而PGR阴性患者的2年存活率仅为51%。
Levels of oestrogen receptor (ER) and progesterone receptor (PgR) in ovarian cancer tissue were examined with regard to their prognostic importance for survival in 179 patients with primary epithelial ovarian cancer stage III or IV in relation to: FIGO-stage, histological type, histological grade, age, ascites, and postorerative residual tumour. Hormone receptor content was determined with the DCC-method, receptor values higher than 9 fmol/mg protein were considered positive. Response to postoperative chemotherapy was significantly correlated with PgR content (80% responders in the group with PgR positive tumours and only 61% responders in the group with PgR negative tumours). A Cox proportional hazards regression model identified histological grade, residual tumour, age and PgR content as independent prognostic factors for survival in advanced epithelial ovarian carcinoma. PgR content had particularly significant prognostic relevance for patients with postoperative residual tumour mass .ltoreq. 2 cm in diameter. Within this group of patients, those who are PgR positive have a 2-years survival probability of 83% compared with only 51% in the PgR-negative group.