α-Glucosidase Inhibition and Antihyperglycemic Activity of Phenolics from the Flowers of Edgeworthia gardneri
α-Glucosidase Inhibition and Antihyperglycemic Activity of Phenolics from the Flowers of Edgeworthia gardneri
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Edgeworthia gardneri 花中酚类物质的 α-葡萄糖苷酶抑制和抗高血糖活性。
DOI：
10.1021/acs.jafc.5b03081
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发表时间：
2015-09-23
影响因子：
6.1
通讯作者：
Zhang, Kun
中科院分区：
文献类型：
--
作者：
Ma, Yan-Yan;Zhao, Deng-Gao;Zhang, Kun
花卉在西藏作为一种具有潜在保健价值的凉茶食用。为了补充目前关于加德纳花的化学成分和降血糖活性的知识，从加德纳花中分离得到两个新的酚类化合物，即加德纳罗A和B(1和2)，以及19个已知的酚类化合物。对所有菌株进行了对α-葡萄糖苷酶的抑制活性评价。化合物5具有明显的α-葡萄糖苷酶抑制活性，是一种竞争性抑制物，被鉴定为加德纳花的主要成分。口服化合物5 300 mg/kg可显著降低正常和链脲佐菌素(STZ)诱导的糖尿病小鼠的餐后血糖水平。此外，化合物5显著降低STZ诱导的糖尿病小鼠的空腹血糖水平。
The flowers of Edgeworthia gardneri are consumed as an herbal tea in Tibet with potential health benefits. To complement the current knowledge regarding the chemical composition and antihyperglycemic activity of the flower of E. gardneri, two new phenolics, gardnerol A and B (1 and 2), along with 19 known phenolics were isolated from the flower of E. gardneri. All isolates were evaluated for their inhibitory activity against α-glucosidase. Compound 5, identified as the major constituent of the flower of E. gardneri, showed a significant α-glucosidase inhibitory activity and acted as a competitive inhibitor. The oral administration of compound 5 at a dose of 300 mg/kg significantly reduced the postprandial blood glucose levels of normal and streptozotocin (STZ)-induced diabetic mice. Furthermore, compound 5 significantly decreased the fasting blood glucose levels in STZ-induced diabetic mice.